ArticleCardiovascular diabetology2013
Impaired skin microcirculation in paediatric patients with type 1 diabetes mellitus.
Article in Cardiovascular diabetology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Neurovascular microcirculatory vasodilation mediated by C-fibers and Transient receptor potential vanilloid-type-1 channels (TRPV 1) is impaired in type 1 diabetes.Scientific reports · 2017Trial
- Cardiovascular and autonomic nervous system response to graded exercise in adolescents with type 1 diabetes.Frontiers in endocrinology · 2026Article
- Gender-Related Difference in Skin Oxygenation in Young Patients with Uncomplicated Type 1 Diabetes.Biomedicines · 2024Article
- Diabetes and climate change: current evidence and implications for people with diabetes, clinicians and policy stakeholders.Diabetologia · 2023Review
- Metformin attenuates high glucose-induced injury in islet microvascular endothelial cells.Bioengineered · 2022Article
- Establishing reference values for macro- and microvascular measurements in 4-to-5 year-old children of the ENVIRONAGE prospective birth cohort.Scientific reports · 2020Article
- Endothelial-Dependent Vasomotor Dysfunction in Infants After Cardiopulmonary Bypass.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020Observational
- Exhaled volatile substances in children suffering from type 1 diabetes mellitus: results from a cross-sectional study.Scientific reports · 2019Article
- Visualization of skin microvascular dysfunction of type 1 diabetic mice using in vivo skin optical clearing method.Journal of biomedical optics · 2018Article
- The corneal subbasal nerve plexus and thickness of the retinal layers in pediatric type 1 diabetes and matched controls.Scientific reports · 2018Article
- Assessing Microvascular Function in Humans from a Chronic Disease Perspective.Journal of the American Society of Nephrology : JASN · 2017Review
- Development of a Diabetes Mellitus Knowledge Resource for Clinical Decision Support Assisting Primary Care Physicians With Work-Related Issues.Journal of occupational and environmental medicine · 2017Article
- Microcirculation, Adiposity, and Traditional and Emerging Cardiovascular Risk Factors in Prepubertal Children.Journal of the Endocrine Society · 2017Article
- Endothelial dysfunction during long-term follow-up in children with STEC hemolytic-uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2017Article
- Current concepts of active vasodilation in human skin.Temperature (Austin, Tex.) · 2017Review
- In situ eNOS/NO up-regulation-a simple and effective therapeutic strategy for diabetic skin ulcer.Scientific reports · 2016Article
- Article
- Assessing endothelial dysfunction in adolescents and young adults with type 1 diabetes mellitus using a non-invasive heat stimulus.Pediatric diabetes · 2015Article
- Urine π-Glutathione S-transferase but not Tamm-Horsfall protein correlates with carotid artery intima media thickness in childhood type1 diabetes.BMC cardiovascular disorders · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisWe used Laser Doppler Fluximetry (LDF) to define "normal" endothelial function in a large cohort of healthy children and adolescents and to evaluate skin microcirculation in paediatric patients with type 1 diabetes mellitus.
methodsLDF was performed in 102 healthy children (12.8 ± 3.3 years of age; 48 male) and 68 patients (12.9 ± 3.3 years of age; 33 male). Duration of disease was 5.0 ± 3.97 years. Each participant sequentially underwent three stimulation protocols (localized thermal hyperaemia with localized warming to maximum 40°C, iontophoretic delivery of pilocarpine hydrochloride (PCH) and sodium nitroprusside (SNP)). The maximum relative increase in skin blood flow and the total relative response, i.e. the area under the curve (AUC) to each stimulus (AUCheat, AUCPCH, AUCSNP) was determined. In addition, the area of a right-angled triangle summarizing the time to and the amplitude of the first peak, which represents the axon reflex mediated neurogenic vasodilation (ARR) was calculated.
resultsIn healthy controls, AUCheat, AUCPCH, AUCSNP, and ARR turned out to be independent of sex, age, and anthropometric values. Per parameter the 10th percentile generated from data of healthy controls was used as the lower threshold to define normal endothelial function. Diabetic patients showed significantly reduced vasodilatative response to either physical or pharmacological stimulation with SNP, whereas the response to PCH was comparable in both cohorts. In patients compared to controls i) a significantly higher frequency of impaired vasodilatation in response to heat and SNP was noted and ii) vascular response was classified as pathological in more than one of the parameters with significantly higher frequency. CONCLUSIONS/
interpretationSkin microvascular endothelial dysfunction is already present in about 25% of paediatric type 1 diabetic patients suffering from type 1 diabetes for at least one year. Future studies are needed to assess the predictive value of endothelial dysfunction in the development of long-term (cardio)vascular comorbidity in these patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.