Evidence map›Paper›PMID 23937598›Full record

Trial reportExperimental and clinical psychopharmacology2013

A human alcohol self-administration paradigm to model individual differences in impaired control over alcohol use.

Robert F Leeman, William R Corbin, Christine Nogueira, Suchitra Krishnan-Sarin, Marc N Potenza, Stephanie S O'Malley

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Experimental and clinical psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. More behavioral recommendations produce more change: A meta-analysis of efficacy of multibehavior recommendations to reduce nonmedical substance use.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
    Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Faster self-paced rate of drinking for alcohol mixed with energy drinks versus alcohol alone.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2017
    Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. To Infuse or Ingest in Human Laboratory Alcohol Research.Alcoholism, clinical and experimental research · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Robert F LeemanDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA. robert.leeman@yale.edu
William R Corbin
Christine Nogueira
Suchitra Krishnan-Sarin
Marc N Potenza
Stephanie S O'Malley
Yale University · US

Funding

Translational Research of Cocaine, Striatum, and ImpulsivitiesP20DA027844 · NIDA · YALE UNIVERSITY · PI POTENZA, MARC N · 2010 to 2013
$3.6M
Mediators and Moderators of BSFT for Adolescent Drug UseR01DA017539 · NIDA · UNIVERSITY OF ARIZONA · PI SHOHAM, VARDA · 2003 to 2007
$2.5M
Improving Alcoholism TreatmentK05AA014715 · NIAAA · YALE UNIVERSITY · PI O'MALLEY, STEPHANIE S · 2004 to 2013
$2.1M
fMRI of Stress & Self-Control in Smoking & Obesity (7 of 14)RL1AA017539 · NIAAA · YALE UNIVERSITY · PI POTENZA, MARC N · 2007 to 2011
$1.3M
Difficulties with Self-Control and High-Risk Alcohol Use in Young AdultsK01AA019694 · NIAAA · YALE UNIVERSITY · PI LEEMAN, ROBERT F · 2010 to 2014
$705k
NIAAA NIH HHS K01 AA 019694NIAAA NIH HHS K01 AA019694NIAAA NIH HHS K05 AA014715NIAAA NIH HHS RL1 AA017539NIDA NIH HHS P20 DA027844NIDA NIH HHS R01 DA017539NIDA NIH HHS RL1 DA017539
6 · The paper itself

Abstract

We developed an alcohol self-administration paradigm to model individual differences in impaired control. The paradigm includes moderate drinking guidelines meant to model limits on alcohol consumption, which are typically exceeded by people with impaired control. Possible payment reductions provided a disincentive for excessive drinking. Alcohol use above the guideline, despite possible pay reductions, was considered to be indicative of impaired control. Heavy-drinking 21- to 25-year-olds (n = 39) were randomized to an experimental condition including the elements of the impaired control paradigm or to a free-drinking condition without these elements. Alcohol self-administration was compared between these two conditions to establish the internal validity of the experimental paradigm. In both conditions, participants self-administered beer and nonalcoholic beverages for 3 hours in a bar setting with 1-3 other participants. Experimental condition participants self-administered significantly fewer beers and drank to lower blood-alcohol concentrations (BACs) on average than those in the free-drinking condition. Experimental condition participants were more likely than free-drinking condition participants to intersperse nonalcoholic beverages with beer and to drink at a slower pace. Although experimental condition participants drank more moderately than those in the free-drinking condition overall, their range of drinking was considerable (BAC range = .024-.097), with several participants drinking excessively. A lower initial subjective response to alcohol and earlier age of alcohol use onset were associated with greater alcohol self-administration in the experimental condition. Given the variability in response, the impaired control laboratory paradigm may have utility for preliminary tests of novel interventions in future studies and for identifying individual differences in problem-drinking risk.

Indexed as

Behavior TherapyModels, PsychologicalAdultAlcohol DrinkingAlcoholic IntoxicationAlcoholismBreath TestsEthanolFemaleGuidelines as TopicHealth PromotionHumansMalePatient Education as TopicPeer GroupRewardEthanol

Identifiers

PMID23937598
PMCPMC4131292
OpenAlexW2024568318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.