Trial reportExperimental and clinical psychopharmacology2013
Marijuana's dose-dependent effects in daily marijuana smokers.
Trial report in Experimental and clinical psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Systematic review and rationale of using psychedelics in the treatment of cannabis use disorder.Frontiers in psychiatry · 2023Pooled it
- Nonmedical Marijuana Use and Cardiovascular Events: A Systematic Review.Public health reports (Washington, D.C. : 1974)Pooled it
- Acute and Extended Anxiolytic Effects of Cannabidiol in Cannabis Flower: A Quasi-ExperimentalCannabis and cannabinoid research · 2024Trial
- ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Acute effects of cannabinoids on symptoms of obsessive-compulsive disorder: A human laboratory study.Depression and anxiety · 2020Trial
- Human behavioral pharmacology of cannabis: Insights on cannabis use disorder.Preventive medicine · 2026Article
- Cannabinoid Exposure and Subjective Effects of THC and CBD in Edible Cannabis Products.Cannabis and cannabinoid research · 2024Observational
- Anxiety sensitivity and cigarette use on cannabis use problems, perceived barriers for cannabis cessation, and self-efficacy for quitting among adults with cannabis use disorder.Addictive behaviors · 2023Article
- The Relationship Between Cannabis, Cognition, and Schizophrenia: It's Complicated.Current topics in behavioral neurosciences · 2023Article
- Use of a Novel EEG-Based Objective Test, the CognalyzerNeurology and therapy · 2022Article
- Effects of repeated adolescent exposure to cannabis smoke on cognitive outcomes in adulthood.Journal of psychopharmacology (Oxford, England) · 2021Article
- Investigating sex differences in acute intoxication and verbal memory errors after ad libitum cannabis concentrate use.Drug and alcohol dependence · 2021Article
- Development and validation of an open-source, disposable, 3D-printedERJ open research · 2021Article
- Human Laboratory Models of Cannabis Use: Applications for Clinical and Translational Psychiatry Research.Frontiers in psychiatry · 2021Article
- Association of Naturalistic Administration of Cannabis Flower and Concentrates With Intoxication and Impairment.JAMA psychiatry · 2020Observational
- Article
- Drug-induced stress responses and addiction risk and relapse.Neurobiology of stress · 2019Review
- Marijuana Use Episodes and Partner Intimacy Experiences: A Daily Report Study.Cannabis (Albuquerque, N.M.) · 2019Article
- Cannabis Use: Neurobiological, Behavioral, and Sex/Gender Considerations.Current behavioral neuroscience reports · 2018Article
- The potential impact of cannabis legalization on the development of cannabis use disorders.Preventive medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Active marijuana produces significant subjective, psychomotor, and physiological effects relative to inactive marijuana, yet demonstrating that these effects are dose-dependent has proven difficult. This within-subject, double-blind study was designed to develop a smoking procedure to obtain a marijuana dose-response function. In four outpatient laboratory sessions, daily marijuana smokers (N = 17 males, 1 female) smoked six 5-s puffs from 3 marijuana cigarettes (2 puffs/cigarette). The number of puffs from active (≥5.5% Δ⁹-tetrahydrocannabinol/THC) and inactive (0.0% THC) marijuana varied according to condition (0, 2, 4, or 6 active puffs); active puffs were always smoked before inactive puffs. Subjective, physiological, and performance effects were assessed prior to and at set time points after marijuana administration. Active marijuana dose-dependently increased heart rate and decreased marijuana craving, despite evidence (carbon monoxide expiration, weight of marijuana cigarettes post-smoking) that participants inhaled less of each active marijuana cigarette than inactive cigarettes. Subjective ratings of marijuana "strength," "high," "liking," "good effect," and "take again" were increased by active marijuana compared with inactive marijuana, but these effects were not dose-dependent. Active marijuana also produced modest, non-dose-dependent deficits in attention, psychomotor function, and recall relative to the inactive condition. In summary, although changes in inhalation patterns as a function of marijuana strength likely minimized the difference between dose conditions, dose-dependent differences in marijuana's cardiovascular effects and ratings of craving were observed, whereas subjective ratings of marijuana effects did not significantly vary as a function of dose.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.