ArticleThe European journal of neuroscience2013
The dopamine patchwork of the rat nucleus accumbens core.
Article in The European journal of neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Toward Precise Modeling of Dopamine Release Kinetics: Comparison and Validation of Kinetic Models Using Voltammetry.ACS omega · 2024Article
- 3D fuzzy graphene microelectrode array for dopamine sensing at sub-cellular spatial resolution.Biosensors & bioelectronics · 2021Article
- Cocaine-Induced Changes in Tonic Dopamine Concentrations Measured Using Multiple-Cyclic Square Wave VoltammetryFrontiers in pharmacology · 2021Article
- Direct dopamine terminal regulation by local striatal microcircuitry.Journal of neurochemistry · 2020Review
- Regional Variation in Striatal Dopamine Spillover and Release Plasticity.ACS chemical neuroscience · 2020Article
- Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes.Biosensors & bioelectronics · 2017Article
- Dopamine dynamics and cocaine sensitivity differ between striosome and matrix compartments of the striatum.Neuropharmacology · 2016Article
- Kinetic diversity of dopamine transmission in the dorsal striatum.Journal of neurochemistry · 2015Article
- The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations.Frontiers in behavioral neuroscience · 2015Article
- Understanding the role α7 nicotinic receptors play in dopamine efflux in nucleus accumbens.ACS chemical neuroscience · 2014Article
- A novel restricted diffusion model of evoked dopamine.ACS chemical neuroscience · 2014Review
- Region- and domain-dependent action of nomifensine.The European journal of neuroscience · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The dopamine (DA) terminal field in the rat dorsal striatum is organized as a patchwork of domains that show distinct DA kinetics. The rate and short-term plasticity of evoked DA release, the rate of DA clearance and the actions of several dopaminergic drugs are all domain-dependent. The patchwork arises in part from local variations in the basal extracellular concentration of DA, which establishes an autoinhibitory tone in slow but not fast domains. The present study addressed the hypothesis that a domain patchwork might also exist in the nucleus accumbens core (NAcc), a DA terminal field that is deeply involved in reward processing and the mechanisms underlying substance abuse. DA recordings in the NAcc by fast-scan voltammetry during electrical stimulation of the medial forebrain bundle confirmed that the NAcc contains a patchwork of fast and slow domains showing significantly different rates of evoked DA release and DA clearance. Moreover, the NAcc domains are substantially different from those in the dorsal striatum. There were no signs in the NAcc of short-term plasticity of DA release during multiple consecutive stimuli, and no signs of a domain-dependent autoinhibitory tone. Thus, the NAcc domains are distinct from each other and from the domains of the dorsal striatum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.