ReviewAnnual review of cell and developmental biology2013
Beyond the niche: tissue-level coordination of stem cell dynamics.
Review in Annual review of cell and developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Toll signalling controls intestinal regeneration in Drosophila.Development (Cambridge, England) · 2026Article
- Organ function is preserved despite reorganization of niche architecture in the hair follicle.Cell stem cell · 2023Article
- Tissue Homeostasis and Non-Homeostasis: From Cell Life Cycles to Organ States.Annual review of cell and developmental biology · 2022Review
- Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea.Nature cell biology · 2021Article
- Towards systems tissue engineering: Elucidating the dynamics, spatial coordination, and individual cells driving emergent behaviors.Biomaterials · 2020Review
- Comparison of culture media indicates a role for autologous serum in enhancing phenotypic preservation of rabbit limbal stem cells in explant culture.Cytotechnology · 2018Article
- Cancer Stem Cells: Emergent Nature of Tumor Emergency.Frontiers in genetics · 2018Article
- Tissue-resident stem cell activity: a view from the adult Drosophila gastrointestinal tract.Cell communication and signaling : CCS · 2017Review
- Article
- Stem Cell Extracellular Vesicles: Extended Messages of Regeneration.Annual review of pharmacology and toxicology · 2017Review
- Advances in the Use of Stem Cells in Veterinary Medicine: From Basic Research to Clinical Practice.Scientifica · 2016Review
- Multipotent versus differentiated cell fate selection in the developing Drosophila airways.eLife · 2015Article
- Evodiamine inhibits proliferation and induces apoptosis in gastric cancer cells.Oncology letters · 2015Article
- Heterotypic control of basement membrane dynamics during branching morphogenesis.Developmental biology · 2015Review
- Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom.Nano today · 2014Article
- Stochastic dynamics of interacting haematopoietic stem cell niche lineages.PLoS computational biology · 2014Article
- Metabolic regulation of stem cell function.Journal of internal medicine · 2014Review
- Combining insoluble and soluble factors to steer stem cell fate.Nature materials · 2014Review
- The ID proteins: master regulators of cancer stem cells and tumour aggressiveness.Nature reviews. Cancer · 2014Review
- Regional specificity in the Drosophila midgut: setting boundaries with stem cells.Cell stem cell · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Adult animals rely on populations of stem cells to ensure organ function throughout their lifetime. Stem cells are governed by signals from stem cell niches, and much is known about how single niches promote stemness and direct stem cell behavior. However, most organs contain a multitude of stem cell-niche units, which are often distributed across the entire expanse of the tissue. Beyond the biology of individual stem cell-niche interactions, the next challenge is to uncover the tissue-level processes that orchestrate spatial control of stem-based renewal, repair, and remodeling throughout a whole organ. Here we examine what is known about higher order mechanisms for interniche coordination in epithelial organs, whose simple geometry offers a promising entry point for understanding the regulation of niche number, distribution, and activity. We also consider the potential existence of stem cell territories and how tissue architecture may influence niche coordination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.