Trial reportJournal of consulting and clinical psychology2013
D-cycloserine augmentation of cognitive behavioral group therapy of social anxiety disorder: prognostic and prescriptive variables.
Trial report in Journal of consulting and clinical psychology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Augmentation of cognitive and behavioural therapies (CBT) with d-cycloserine for anxiety and related disorders.The Cochrane database of systematic reviews · 2015Pooled it
- The desire to belong: Social identification as a predictor of treatment outcome in social anxiety disorder.Behaviour research and therapy · 2016Trial
- Predictors of dropout in concurrent treatment of posttraumatic stress disorder and alcohol dependence: Rate of improvement matters.Behaviour research and therapy · 2016Trial
- Concurrent treatment of posttraumatic stress disorder and alcohol dependence: Predictors and moderators of outcome.Journal of consulting and clinical psychology · 2016Trial
- Augmenting serotonin reuptake inhibitors in obsessive-compulsive disorder: What moderates improvement?Journal of consulting and clinical psychology · 2015Trial
- Dose timing of D-cycloserine to augment cognitive behavioral therapy for social anxiety: Study design and rationale.Contemporary clinical trials · 2015Trial
- Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy Data.Cognitive behaviour therapy · 2015Trial
- Sleep quality predicts treatment outcome in CBT for social anxiety disorder.Depression and anxiety · 2013Trial
- D-cycloserine enhancement of exposure therapy for social anxiety disorder depends on the success of exposure sessions.Journal of psychiatric research · 2013Trial
- Moderators of Internet-Delivered Cognitive-Behavioral Therapy for Adolescents With Chronic Pain: Who Benefits From Treatment at Long-Term Follow-Up?The journal of painTrial
- Enhancing the Efficacy of Exposure Therapy: Translation of Pharmacological Augmentation of Fear Extinction.Annual review of clinical psychology · 2026Review
- Prefrontal cortex hypoactivity distinguishes severe from mild-to-moderate social anxiety as revealed by a palm-sized near-infrared spectroscopy system.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Emotional Modulation of Learning and Memory: Pharmacological Implications.Pharmacological reviews · 2017Review
- What good are positive emotions for treatment? Trait positive emotionality predicts response to Cognitive Behavioral Therapy for anxiety.Behaviour research and therapy · 2017Article
- The effect of D-cycloserine on social anxiety treatment using a behavioral outcome measure and a post-session administration strategy.Behavior analysis (Washington, D.C.) · 2016Article
- Article
- Therapeutic Process During Exposure: Habituation Model.Journal of obsessive-compulsive and related disorders · 2015Article
- Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders.Pharmacology & therapeutics · 2015Review
- D-cycloserine augmentation of cognitive behavioral therapy for anxiety disorders: an update.Current psychiatry reports · 2015Review
- Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveThe aim of the current study was to identify individual characteristics that (a) predict symptom improvement with group cognitive behavioral therapy (CBT) for social anxiety disorder (SAD; i.e., prognostic variables) or (b) moderate the effects of d-cycloserine (DCS) versus placebo augmentation of CBT for SAD (i.e., prescriptive variables).
methodAdults with SAD (N = 169) provided Liebowitz Social Anxiety Scale scores in a trial evaluating DCS augmentation of group CBT. Rate of symptom improvement during therapy and posttreatment symptom severity were evaluated using multilevel modeling. As predictors of these 2 parameters, we selected the range of variables assessed at baseline (demographic characteristics, clinical characteristics, personality traits). Using step-wise analyses, we first identified prognostic and prescriptive variables within each of these domains and then entered these significant predictors simultaneously in 1 final model.
resultsAfrican American ethnicity and cohabitation status were associated with greater overall rates of improvement during therapy and lower posttreatment severity. Higher initial severity was associated with a greater improvement during therapy but also higher posttreatment severity (the greater improvement was not enough to overcome the initial higher severity). DCS augmentation was evident only among individuals low in conscientiousness and high in agreeableness.
conclusionsAfrican American ethnicity, cohabitation status, and initial severity are prognostic of favorable CBT outcomes in SAD. DCS augmentation appears particularly useful for patients low in conscientiousness and high in agreeableness. These findings can guide clinicians in making decisions about treatment strategies and can help direct research on the mechanisms of these treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.