ArticleBMC developmental biology2013
The role of Zic transcription factors in regulating hindbrain retinoic acid signaling.
Article in BMC developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Dual role of ZIC2 during neural induction: from priming transcription factor to enhancer activator.Nucleic acids research · 2026Article
- Multicondition and multimodal temporal profile inference during mouse embryonic development.Genome research · 2025Article
- ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification.American journal of human genetics · 2024Article
- Multi-condition and multi-modal temporal profile inference during mouse embryonic development.bioRxiv : the preprint server for biology · 2024Article
- Retinoid metabolism: new insights.Journal of molecular endocrinology · 2022Review
- ATRT-SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance.Acta neuropathologica · 2022Article
- An ontology for developmental processes and toxicities of neural tube closure.Reproductive toxicology (Elmsford, N.Y.) · 2021Article
- A novel conserved enhancer at zebrafish zic3 and zic6 loci drives neural expression.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- Case report: a novel mutation in ZIC2 in an infant with microcephaly, holoprosencephaly, and arachnoid cyst.Medicine · 2019Article
- Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.Scientific reports · 2018Article
- Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis.Developmental biology · 2017Article
- Article
- Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport.Nature communications · 2015Article
- ZNF804A Transcriptional Networks in Differentiating Neurons Derived from Induced Pluripotent Stem Cells of Human Origin.PloS one · 2015Article
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Authors and funding
6 authors.
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Abstract
backgroundThe reiterated architecture of cranial motor neurons aligns with the segmented structure of the embryonic vertebrate hindbrain. Anterior-posterior identity of cranial motor neurons depends, in part, on retinoic acid signaling levels. The early vertebrate embryo maintains a balance between retinoic acid synthetic and degradative zones on the basis of reciprocal expression domains of the retinoic acid synthesis gene aldhehyde dehydrogenase 1a2 (aldh1a2) posteriorly and the oxidative gene cytochrome p450 type 26a1 (cyp26a1) in the forebrain, midbrain, and anterior hindbrain.
resultsThis manuscript investigates the role of zinc finger of the cerebellum (zic) transcription factors in regulating levels of retinoic acid and differentiation of cranial motor neurons. Depletion of zebrafish Zic2a and Zic2b results in a strong downregulation of aldh1a2 expression and a concomitant reduction in activity of a retinoid-dependent transgene. The vagal motor neuron phenotype caused by loss of Zic2a/2b mimics a depletion of Aldh1a2 and is rescued by exogenously supplied retinoic acid.
conclusionZic transcription factors function in patterning hindbrain motor neurons through their regulation of embryonic retinoic acid signaling.
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