ArticleBrain connectivity2013
Examination of frontal and parietal tectocortical attention pathways in spina bifida meningomyelocele using probabilistic diffusion tractography.
Article in Brain connectivity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Variation in Neurodegeneration-Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida.Annals of the Child Neurology Society · 2025Article
- Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Long-Term Imaging Follow-up from the Management of Myelomeningocele Study.AJNR. American journal of neuroradiology · 2023Article
- Hydrocephalus and school-age neurodevelopmental outcomes in the management of myelomeningocele prenatal surgery trial: a secondary analysis.Journal of neurosurgery. Pediatrics · 2023Article
- Emerging magnetic resonance imaging techniques in open spina bifida in utero.European radiology experimental · 2021Review
- Ventricular volume and neurocognitive outcome after endoscopic third ventriculostomy: is shunting a better option? A review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
- Plasticity of Interhemispheric Temporal Lobe White Matter Pathways Due to Early Disruption of Corpus Callosum Development in Spina Bifida.Brain connectivity · 2016Article
- Structural Connectivity Networks of Transgender People.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Spina bifida.Nature reviews. Disease primers · 2015Review
- Attention in spina bifida myelomeningocele: Relations with brain volume and integrity.NeuroImage. Clinical · 2015Article
- Covert orienting in three etiologies of congenital hydrocephalus: the effect of midbrain and posterior fossa dysmorphology.Journal of the International Neuropsychological Society : JINS · 2014Article
- Anatomical and diffusion MRI of deep gray matter in pediatric spina bifida.NeuroImage. Clinical · 2014Article
- Neuropsychological care guidelines for people with spina bifida.Journal of pediatric rehabilitation medicineReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Abnormalities of the midbrain tectum are common but variable malformations in spina bifida meningomyelocele (SBM) and have been linked to neuropsychological deficits in attention orienting. The degree to which variations in tectum structure influence white matter (WM) connectivity to cortical regions is unknown. To assess the relationship of tectal structure and connectivity to frontal and parietal cortical regions, probabilistic diffusion tractography was performed on 106 individuals (80 SBM, 26 typically developing [TD]) to isolate anterior versus posterior tectocortical WM pathways. Results showed that those with SBM exhibited significantly reduced tectal volume, along with decreased fractional anisotropy (FA) in posterior but not anterior tectocortical WM pathways when compared with TD individuals. The group with SBM also showed greater within-subject discrepancies between frontal and parietal WM integrity compared with the TD group. Of those with SBM, qualitative classification of tectal beaking based on radiological review was associated with increased axial diffusivity across both anterior and posterior tectocortical pathways, relative to individuals with SBM and a normal appearing tectum. These results support previous volumetric findings of greater impairment to posterior versus anterior brain regions in SBM, and quantifiably relate tectal volume, tectocortical WM integrity, and tectal malformations in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.