ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2013
iTRAQ-based proteomics reveals novel biomarkers of osteoarthritis.
Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Global research trends and hotspots for leukocyte cell-derived chemotaxin-2 from the past to 2023: a combined bibliometric review.Frontiers in immunology · 2024Pooled it
- Current cutting-edge omics techniques on musculoskeletal tissues and diseases.Bone research · 2025Review
- Therapeutic prospects and potential mechanisms of Prdx6: as a novel target in musculoskeletal disorders.Frontiers in physiology · 2025Review
- A Narrative Review of the Roles of Chondromodulin-I (Cnmd) in Adult Cartilage Tissue.International journal of molecular sciences · 2024Review
- Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms.Bone research · 2023Review
- Development of novel isobaric tags enables accurate and sensitive multiplexed proteomics using complementary ions.Analytical and bioanalytical chemistry · 2023Article
- The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases: From mechanisms to therapeutic potential.Frontiers in immunology · 2023Review
- Role of peroxiredoxin 6 in the chondroprotective effects of microvesicles from human adipose tissue-derived mesenchymal stem cells.Journal of orthopaedic translation · 2021Article
- Protein Levels and Microstructural Changes in Localized Regions of Early Cartilage Degeneration Compared with Adjacent Intact Cartilage.Cartilage · 2021Article
- Primary human chondrocytes respond to compression with phosphoproteomic signatures that include microtubule activation.Journal of biomechanics · 2019Article
- Effects of ultrasound therapy on the synovial fluid proteome in a rabbit surgery-induced model of knee osteoarthritis.Biomedical engineering online · 2019Article
- The change of synovial fluid proteome in rabbit surgery-induced model of knee osteoarthritis.American journal of translational research · 2018Article
- Leukocyte Cell-Derived Chemotaxin-2: It's Role in Pathophysiology and Future in Clinical Medicine.Clinical and translational science · 2017Review
- Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force.Scientific reports · 2015Article
- Proteomic Analysis of Engineered Cartilage.Methods in molecular biology (Clifton, N.J.) · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe performed comprehensive proteomic analyses of articular cartilage by using the isobaric tags for relative and absolute quantitation (iTRAQ) method, and searched for candidate biomarkers for osteoarthritis (OA).
methodsArticular cartilage was collected from patients with OA or femoral neck fracture for the control group. Molecular variations were detected by the iTRAQ method, and quantitative analyses were performed by western blot.
resultsUsing the iTRAQ method, we identified 76 proteins with different expression levels in OA patients and the control group. Among these proteins, we selected LECT2 (leukocyte cell-derived chemotaxin-2), BAALC (brain and acute leukemia, cytoplasmic), and PRDX6 (peroxiredoxin-6), which had not been reported as biomarkers for OA.
conclusionsUse of these proteins in combination with conventional OA biomarkers may better reflect the grade and prognosis of OA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.