Evidence map›Paper›PMID 23936871›Full record

ArticleJournal of regenerative medicine2013

Human Stem Cell Derivatives Retain More Open Epigenomic Landscape When Derived from Pluripotent Cells than from Tissues.

Xuejun H Parsons

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of regenerative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Xuejun H ParsonsSan Diego Regenerative Medicine Institute, San Diego, USA ; Xcelthera, San Diego, USA.

Funding

Epigenetic Controls in hESC Dopaminergic FateK01AG024496 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PARSONS, XUEJUN H · 2005 to 2009
$610k
Mapping hESC neuronal lineage programmingR21HD056530 · NICHD · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI PARSONS, XUEJUN H · 2009 to 2010
$415k
NIA NIH HHS K01 AG024496NICHD NIH HHS R21 HD056530
6 · The paper itself

Abstract

The growing number of identified stem cell derivatives and escalating concerns for safety and efficacy of these cells towards clinical applications have made it increasingly crucial to be able to assess the relative risk-benefit ratio of a given stem cell from a given source for a particular disease. Discerning the intrinsic plasticity and regenerative potential of human stem cell populations might reside in chromatin modifications that shape the respective epigenomes of their derivation routes. Previously, we have generated engraftable human neuronal progenitors direct from pluripotent human embryonic stem cells (hESCs) by small molecule induction (hESC-I hNuPs). Unlike the prototypical neuroepithelial-like nestin-positive human neural stem cells (hNSCs), these

Indexed as

AcetylationCell therapyChIP-on-ChipChromatinDevelopmentDifferentiationEpigenomeHuman embryonic stem cellsHuman neural stem cellsHuman neuronal progenitorsHuman pluripotent stem cellsHuman stem cell derivativeLineage-specificMethylationNeuronsOct-4Regenerative medicine

Identifiers

PMID23936871
PMCPMC3736349

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.