ReviewBioMed research international2013
Hyperpolarization-activated current, If, in mathematical models of rabbit sinoatrial node pacemaker cells.
Review in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Pharmacological Preconditioning with Diazoxide Upregulates HCN4 Channels in the Sinoatrial Node of Adult Rat Cardiomyocytes.International journal of molecular sciences · 2025Article
- Bidirectional flow of the funny current (IProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Calibration of ionic and cellular cardiac electrophysiology models.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Cardiac Pacemaker Activity and Aging.Annual review of physiology · 2020Review
- A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources.The Journal of physiology · 2019Article
- Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics.The Journal of physiology · 2017Review
- Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review).International journal of molecular medicine · 2017Review
- The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock Pacemaker Cell Mechanisms.Frontiers in physiology · 2016Article
- Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K⁺ Current: A Simulation Study.BioMed research international · 2016Article
- The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat.Frontiers in physiology · 2015Review
- I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes.Journal of molecular and cellular cardiology · 2014Article
- Effects of maximal sodium and potassium conductance on the stability of Hodgkin-Huxley model.Computational and mathematical methods in medicine · 2014Article
- Modern perspectives on numerical modeling of cardiac pacemaker cell.Journal of pharmacological sciences · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A typical feature of sinoatrial (SA) node pacemaker cells is the presence of an ionic current that activates upon hyperpolarization. The role of this hyperpolarization-activated current, If, which is also known as the "funny current" or "pacemaker current," in the spontaneous pacemaker activity of SA nodal cells remains a matter of intense debate. Whereas some conclude that If plays a fundamental role in the generation of pacemaker activity and its rate control, others conclude that the role of If is limited to a modest contribution to rate control. The ongoing debate is often accompanied with arguments from computer simulations, either to support one's personal view or to invalidate that of the antagonist. In the present paper, we review the various mathematical descriptions of If that have been used in computer simulations and compare their strikingly different characteristics with our experimental data. We identify caveats and propose a novel model for If based on our experimental data.
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