ArticleBioMed research international2013
Long-term impact of immunosuppressants at therapeutic doses on male reproductive system in unilateral nephrectomized rats: a comparative study.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Calcineurin Inhibitors and Male Fertility in Renal Transplant Recipients: A Comprehensive Review of Molecular Pathomechanisms and Reproductive Toxicity of Cyclosporine A and Tacrolimus.International journal of molecular sciences · 2026Review
- Subchronic Cadmium-Induced Xenobiotic Toxicity in Male Wistar Rats: Antioxidant and Reproductive Protection by Standardized Silymarin with Molecular Docking Insights.Journal of xenobiotics · 2026Article
- Pregnancy in Patients With Renal Transplant.O&G open · 2026Review
- The treatment based on calcineurin inhibitors and their conversion to sirolimus alter the morphology in the rat testis.Scientific reports · 2025Article
- Testosterone Deficiency as One of the Major Endocrine Disorders in Chronic Kidney Disease.Nutrients · 2022Review
- The Effects of Long-Term Immunosuppressive Therapies on the Structure of the Rat Prostate.International journal of environmental research and public health · 2020Article
- Erectile Dysfunction after Kidney Transplantation.Journal of clinical medicine · 2020Review
- Low dose bitter leaf improves sperm quality disrupted in immunosuppressed Wistar rats: An experimental study.International journal of reproductive biomedicine · 2020Article
- Article
- Molecular Mechanisms Controlled by mTOR in Male Reproductive System.International journal of molecular sciences · 2019Review
- Male infertility in renal failure and transplantation.Translational andrology and urology · 2019Review
- Mammalian target of rapamycin (mTOR): a central regulator of male fertility?Critical reviews in biochemistry and molecular biology · 2017Review
- mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice.Biology of reproduction · 2016Article
- Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo.Developmental biology · 2015Article
- Effects of an immunosuppressive treatment on the rat prostate.Drug design, development and therapyArticle
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclosporine, tacrolimus, and sirolimus are commonly used in renal transplant recipients to prevent rejection. However, information for comparative effects of these agents on the male productive system is extremely limited and controversial. In a physiologically and clinically relevant rat model of unilateral nephrectomy, we demonstrated that long-term oral administration of both cyclosporine and sirolimus at doses equivalent to the therapeutic levels used for postrenal transplant patients significantly affects testicular development and the hypothalamic-pituitary-gonadal axis accompanied by profound histological changes of testicular structures on both light and electron microscopic examinations. Spermatogenesis was also severely impaired as indicated by low total sperm counts along with reduction of sperm motility and increase in sperm abnormality after treatment with these agents, which may lead to male infertility. On the other hand, treatment with therapeutic dose of tacrolimus only induced mild reduction of sperm count without histological evidence of testicular injury. The current study clearly demonstrates that commonly used immunosuppressants have various impacts on male reproductive system even at therapeutic levels. Our data provide useful information for the assessment of male infertility in renal transplant recipients who wish to father children. Clinical trials to address these issues should be urged.
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