ReviewBioMed research international2013
Acetylcholinesterase as a biomarker in environmental and occupational medicine: new insights and future perspectives.
Review in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06021262 (Assessment of the Prognostic Value of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity), which is not on this map. Cited by 122 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of the Prognostic Value of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity
Who cites it
122 citing papers in PubMed, 1 synthesis or guideline pooled it, 457 citations in OpenAlex.
- Salivary Biomarkers for Alzheimer's Disease: A Systematic Review with Meta-Analysis.International journal of molecular sciences · 2024Pooled it
- Protective Effects of Selenium Against TiZn Nanocomposite-Induced Oxidative Stress and Neurotoxicity in the Freshwater Mussel Unio ravoisieri.Environmental toxicology · 2026Article
- Duration of Caloric Restriction Modulates Brain Redox Adaptation and Frailty During Aging.International journal of molecular sciences · 2026Article
- Chronic Study on the Environmentally Relevant Concentration of Cytotoxic Drug Cyclophosphamide on the Biochemical Responses of the Freshwater Mussel Lamellidens marginalis.Applied biochemistry and biotechnology · 2026Article
- Tissue-Specific Biomarkers and Bioaccumulation inJournal of xenobiotics · 2026Article
- Rabbit Litter-Derived Carbon Materials for Organophosphate Pesticide Mitigation: Adsorption Performance, Neurotoxicity Reduction, and Genotoxicity Assessment.Journal of xenobiotics · 2026Article
- Cumulative Soil Metal Contamination Reshapes Oxidative and Neuroenzymatic Stress Responses in Ants Across an Industrial Pollution Gradient.Life (Basel, Switzerland) · 2026Article
- PFAS Compounds Display Distinct Toxicological Effects inBiomolecules · 2026Article
- Bioaccumulation of toxic and essential elements and enzymatic responses in native fish from the middle Tocantins River.Scientific reports · 2026Article
- Subchronic comparative assessment of graded ferrous sulfate doses on biochemical, histological, and multiorgan micromorphological changes in wistar rats.Open veterinary journal · 2026Article
- ELISA-based assessment of cholinesterase levels in different animal groups: Insights into neurological health.Open veterinary journal · 2026Article
- Indirect exposure to organophosphate pesticides and its possible growth disorders in children of farmers in Northwest Mexico.International archives of occupational and environmental health · 2026Article
- Investigating Hippocampal Lateralization: Effects of Nickel on Neurobiological, AchE Activity, and Neurobehavioral Changes in the Wistar Rats.Molecular neurobiology · 2025Article
- Article
- Comprehensive Biomarker Assessment of Pesticide Exposure and Telomere Attrition in Mexican Children from Agricultural Communities.Journal of xenobiotics · 2025Article
- Effects of exposure to insecticides on sleep and neurobehavioural functioning in puberty and adolescence: a scoping review.Arhiv za higijenu rada i toksikologiju · 2025Article
- Physiological, molecular and histological response of Pentodon bispinosus larvae (Coleoptera: Scarabaeidae) as a novel bioindicator for soil pollutants.Scientific reports · 2025Article
- The Influence of Blood Titanium Levels on DNA Damage in Brazilian Workers Occupationally Exposed to Different Chemical Agents.Biological trace element research · 2025Article
- Single and joint toxicity of ethoprophos and bispyribac-sodium to Oreochromis niloticus: biochemical and genotoxic responses.Fish physiology and biochemistry · 2025Article
- Dual Monitoring of Blood Acetylcholinesterase Content and Catalytic Activity Utilizing Fluorometry-Integrated Surface Plasmon Resonance.Biosensors · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylcholinesterase (AChE) is a key enzyme in the nervous system. It terminates nerve impulses by catalysing the hydrolysis of neurotransmitter acetylcholine. As a specific molecular target of organophosphate and carbamate pesticides, acetylcholinesterase activity and its inhibition has been early recognized to be a human biological marker of pesticide poisoning. Measurement of AChE inhibition has been increasingly used in the last two decades as a biomarker of effect on nervous system following exposure to organophosphate and carbamate pesticides in occupational and environmental medicine. The success of this biomarker arises from the fact that it meets a number of characteristics necessary for the successful application of a biological response as biomarker in human biomonitoring: the response is easy to measure, it shows a dose-dependent behavior to pollutant exposure, it is sensitive, and it exhibits a link to health adverse effects. The aim of this work is to review and discuss the recent findings about acetylcholinesterase, including its sensitivity to other pollutants and the expression of different splice variants. These insights open new perspective for the future use of this biomarker in environmental and occupational human health monitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.