ArticleNeural plasticity2013
System consolidation of spatial memories in mice: effects of enriched environment.
Article in Neural plasticity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Explicitly acquired interrelations among mental schema reduces cognitive load and facilitates emergence of novel responses in mice and artificial neural networks.Experimental brain research · 2026Article
- Context memory formed in medial prefrontal cortex during infancy enhances learning in adulthood.Nature communications · 2024Article
- Article
- Peg Forest Rehabilitation - A novel spatial navigation based cognitive rehabilitation paradigm for experimental neurotrauma.Behavioural brain research · 2023Article
- A robust bitmap-based real-time position tracking algorithm for rats in radial arm maze tests.Scientific reports · 2021Article
- Social housing enhances acquisition of task set independently of environmental enrichment: A longitudinal study in the Barnes maze.Learning & behavior · 2020Article
- Enriched Environment Procedures for Rodents: Creating a Standardized Protocol for Diverse Enrichment to Improve Consistency across Research Studies.Bio-protocol · 2020Article
- Odor modulates the temporal dynamics of fear memory consolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- A contextual binding theory of episodic memory: systems consolidation reconsidered.Nature reviews. Neuroscience · 2019Review
- Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model.Brain, behavior, and immunity · 2019Article
- Environmental enrichment and mouse models: Current perspectives.Animal models and experimental medicine · 2018Review
- Environmental Enrichment Induces Changes in Long-Term Memory for Social Transmission of Food Preference in Aged Mice through a Mechanism Associated with Epigenetic Processes.Neural plasticity · 2018Article
- Hippocampal Mechanisms Underlying Impairment in Spatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBA Mice.Frontiers in systems neuroscience · 2018Article
- Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice.Scientific reports · 2016Article
- Why do lesions in the rodent anterior thalamic nuclei cause such severe spatial deficits?Neuroscience and biobehavioral reviews · 2015Review
- Spatial learning and memory deficits in young adult mice exposed to a brief intense noise at postnatal age.Journal of otology · 2015Article
- Enriched environment prevents cognitive and motor deficits associated with postnatal MK-801 treatment.Psychopharmacology · 2014Article
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental enrichment (EE) is known to enhance learning and memory. Declarative memories are thought to undergo a first rapid and local consolidation process, followed by a prolonged process of system consolidation, which consist in a time-dependent gradual reorganization of brain regions supporting remote memory storage and crucial for the formation of enduring memories. At present, it is not known whether EE can affect the process of declarative memory system consolidation. We characterized the time course of hippocampal and cortical activation following recall of progressively more remote spatial memories. Wild-type mice either exposed to EE for 40 days or left in standard environment were subjected to spatial learning in the Morris water maze and to the probe test 1, 10, 20, 30, and 50 days after learning. Following the probe test, regional expression of the inducible immediate early gene c-Fos was mapped by immunohistochemistry, as an indicator of neuronal activity. We found that activation of the medial prefrontal cortex (mPFC), suggested to have a privileged role in processing remote spatial memories, was evident at shorter time intervals after learning in EE mice; in addition, EE induced the progressive activation of a distributed cortical network not activated in non-EE mice. This suggests that EE not only accelerates the process of mPFC recruitment but also recruits additional cortical areas into the network supporting remote spatial memories.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.