ArticlePLoS neglected tropical diseases2013
Epidemiology of and impact of insecticide spraying on Chagas disease in communities in the Bolivian Chaco.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for vertical transmission of Chagas disease: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Pooled it
- Neglected parasitic diseases from a one-health perspective: American trypanosomiasis and leishmaniasis in dogs and humans in the Bolivian Chaco.Parasites & vectors · 2025Article
- Knowledge, Attitudes, and Practices toward Chagas Disease: A Cross-Sectional Survey of Bolivians in the Gran Chaco and Latin American Migrants in London.The American journal of tropical medicine and hygiene · 2025Article
- Article
- Chagas disease in immunocompromised patients.Clinical microbiology reviews · 2024Review
- Human Trypanosoma cruzi infection in the Argentinean Chaco: risk factors and identification of households with infected children for treatment.Parasites & vectors · 2024Article
- Irrigation, migration and infestation: a case study of Chagas disease vectors and bed bugs in El Pedregal, Peru.Memorias do Instituto Oswaldo Cruz · 2024Article
- Improving in vitro screening compounds anti-Trypanosoma cruzi by GFP-expressing parasites.Memorias do Instituto Oswaldo Cruz · 2024Article
- The Pampa del Indio project: sustainable vector control and long-term declines in the prevalence and abundance of Triatoma infestans infected with Trypanosoma cruzi in the Argentine Chaco.Parasites & vectors · 2023Article
- Persistence of Trypanosoma cruzi vector-borne transmission among school-age children in the Bolivian Chaco documented by 24-month longitudinal serosurveillance.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2023Article
- Chagas disease in Oklahoma.The American journal of the medical sciences · 2022Review
- Chronic Chagas Disease-the Potential Role of Reinfections in Cardiomyopathy Pathogenesis.Current heart failure reports · 2022Review
- Deep Sequencing to Detect Diversity of Trypanosoma cruzi Infection in Patients Coinfected With Human Immunodeficiency Virus and Chagas Disease.The Journal of infectious diseases · 2022Article
- Article
- Interrogating the transmission dynamics ofFrontiers in cellular and infection microbiology · 2022Article
- Diagnosis and Clinical Management of Chagas Disease: An Increasing Challenge in Non-Endemic Areas.Research and reports in tropical medicine · 2022Review
- Chagas disease control-surveillance in the Americas: the multinational initiatives and the practical impossibility of interrupting vector-borne Trypanosoma cruzi transmission.Memorias do Instituto Oswaldo Cruz · 2022Article
- Risk Factors for Maternal Chagas Disease and Vertical Transmission in a Bolivian Hospital.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Feasibility of a Combined Mobile-Health Electrocardiographic and Rapid Diagnostic Test Screening for Chagas-Related Cardiac Alterations.Microorganisms · 2021Article
- Indoor residual spraying practices against Triatoma infestans in the Bolivian Chaco: contributing factors to suboptimal insecticide delivery to treated households.Parasites & vectors · 2021Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundChagas disease control campaigns relying upon residual insecticide spraying have been successful in many Southern American countries. However, in some areas, rapid reinfestation and recrudescence of transmission have occurred. METHODOLOGY/PRINCIPAL
findingsWe conducted a cross-sectional survey in the Bolivian Chaco to evaluate prevalence of and risk factors for T. cruzi infection 11 years after two rounds of blanket insecticide application. We used a cubic B-spline model to estimate change in force of infection over time based on age-specific seroprevalence data. Overall T. cruzi seroprevalence was 51.7%. The prevalence was 19.8% among children 2-15, 72.7% among those 15-30 and 97.1% among participants older than 30 years. Based on the model, the estimated annual force of infection was 4.3% over the two years before the first blanket spray in 2000 and fell to 0.4% for 2001-2002. The estimated annual force of infection for 2004-2005, the 2 year period following the second blanket spray, was 4.6%. However, the 95% bootstrap confidence intervals overlap for all of these estimates. In a multivariable model, only sleeping in a structure with cracks in the walls (aOR = 2.35; 95% CI = 1.15-4.78), age and village of residence were associated with infection. CONCLUSIONS/SIGNIFICANCE: As in other areas in the Chaco, we found an extremely high prevalence of Chagas disease. Despite evidence that blanket insecticide application in 2000 may have decreased the force of infection, active transmission is ongoing. Continued spraying vigilance, infestation surveillance, and systematic household improvements are necessary to disrupt and sustain interruption of infection transmission.
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