Evidence map›Paper›PMID 23936531›Full record

ArticlePloS one2013

SnoN facilitates axonal regeneration after spinal cord injury.

Jiun L Do, Azad Bonni, Mark H Tuszynski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. What makes a RAG regeneration associated?Frontiers in molecular neuroscience · 2015
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jiun L DoDepartment of Neurosciences, University of California San Diego, La Jolla, California, United States of America.
Azad Bonni
Mark H Tuszynski
University of California, San Diego · USHarvard University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3M
Plasticity and Regeneration in the Primate Spinal CordR01NS042291 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRESNAHAN, JACQUELINE C, CAPITANIO, JOHN P · 2001 to 2015
$13.0M
SIGNAL TRANSDUCTION PATHWAYS REGULATING NEURON SURVIVALR01NS041021 · NINDS · WASHINGTON UNIVERSITY · PI GABEL, HARRISON W · 2001 to 2023
$7.7M
Plasticity and Regeneration in the Primate Spinal CordR56NS042291 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 2017 to 2017
$543k
NIGMS NIH HHS T32 GM007198NINDS NIH HHS NS42291NINDS NIH HHS R01 NS041021NINDS NIH HHS R01 NS042291NINDS NIH HHS R56 NS042291
6 · The paper itself

Abstract

Adult CNS neurons exhibit a reduced capacity for growth compared to developing neurons, due in part to downregulation of growth-associated genes as development is completed. We tested the hypothesis that SnoN, an embryonically regulated transcription factor that specifies growth of the axonal compartment, can enhance growth in injured adult neurons. In vitro, SnoN overexpression in dissociated adult DRG neuronal cultures significantly enhanced neurite outgrowth. Moreover, TGF-β1, a negative regulator of SnoN, inhibited neurite outgrowth, and SnoN over-expression overcame this inhibition. We then examined whether SnoN influenced axonal regeneration in vivo: indeed, expression of a mutant form of SnoN resistant to degradation significantly enhanced axonal regeneration following cervical spinal cord injury, despite peri-lesional upregulation of TGF-β1. Thus, a developmental mechanism that specifies extension of the axonal compartment also promotes axonal regeneration after adult CNS injury.

Indexed as

AnimalsAxonsCells, CulturedFemaleGanglia, SpinalImmunoblottingNerve RegenerationNerve Tissue ProteinsNeuronsRatsRats, Inbred F344Spinal Cord InjuriesTranscription FactorsTransforming Growth Factor beta1Nerve Tissue ProteinsSkil_v1 protein, ratTranscription FactorsTransforming Growth Factor beta1

Identifiers

PMID23936531
PMCPMC3732222
OpenAlexW2146455238

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.