ArticlePloS one2013
Bidirectional modulation of substantia nigra activity by motivational state.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
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- Dopamine dynamics during stimulus-reward learning in mice can be explained by performance rather than learning.Nature communications · 2025Article
- GABAergic neurons in the ventral tegmental area represent and regulate force vectors.Cell reports · 2025Article
- Characterization of striatal dopamine projections across striatal subregions in behavioral flexibility.The European journal of neuroscience · 2023Article
- Premovement activity in the mesocortical system links peak force but not initiation of force generation under incentive motivation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Putting early sensory neurons to sleep.eLife · 2023Article
- Striatal mechanisms of turning behaviour following unilateral dopamine depletion in mice.The European journal of neuroscience · 2022Article
- Reward-specific satiety affects subjective value signals in orbitofrontal cortex during multicomponent economic choice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Ethanol produces multiple electrophysiological effects on ventral tegmental area neurons in freely moving rats.Addiction biology · 2021Article
- Progress in opioid reward research: From a canonical two-neuron hypothesis to two neural circuits.Pharmacology, biochemistry, and behavior · 2021Review
- Mapping excessive "disgust" in the brain: Ventral pallidum inactivation recruits distributed circuitry to make sweetness "disgusting".Cognitive, affective & behavioral neuroscience · 2020Article
- A Head-Fixation System for Continuous Monitoring of Force Generated During Behavior.Frontiers in integrative neuroscience · 2020Article
- Precise Coordination of Three-Dimensional Rotational Kinematics by Ventral Tegmental Area GABAergic Neurons.Current biology : CB · 2019Article
- A striatal interneuron circuit for continuous target pursuit.Nature communications · 2019Article
- Does activation of midbrain dopamine neurons promote or reduce feeding?International journal of obesity (2005) · 2017Article
- Article
- Monkeys choose as if maximizing utility compatible with basic principles of revealed preference theory.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A GABAergic nigrotectal pathway for coordination of drinking behavior.Nature neuroscience · 2016Article
- Luminopsins integrate opto- and chemogenetics by using physical and biological light sources for opsin activation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Neuronal Reward and Decision Signals: From Theories to Data.Physiological reviews · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A major output nucleus of the basal ganglia is the substantia nigra pars reticulata, which sends GABAergic projections to brainstem and thalamic nuclei. The GABAergic (GABA) neurons are reciprocally connected with nearby dopaminergic neurons, which project mainly to the basal ganglia, a set of subcortical nuclei critical for goal-directed behaviors. Here we examined the impact of motivational states on the activity of GABA neurons in the substantia nigra pars reticulata and the neighboring dopaminergic (DA) neurons in the pars compacta. Both types of neurons show short-latency bursts to a cue predicting a food reward. As mice became sated by repeated consumption of food pellets, one class of neurons reduced cue-elicited firing, whereas another class of neurons progressively increased firing. Extinction or pre-feeding just before the test session dramatically reduced the phasic responses and their motivational modulation. These results suggest that signals related to the current motivational state bidirectionally modulate behavior and the magnitude of phasic response of both DA and GABA neurons in the substantia nigra.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.