ArticlePloS one2013
Deletion of thioredoxin reductase and effects of selenite and selenate toxicity in Caenorhabditis elegans.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Selenium-EnrichedAntioxidants (Basel, Switzerland) · 2024Article
- HIF-1 Has a Central Role inFrontiers in genetics · 2020Article
- A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity.Redox biology · 2020Article
- The glutathione system and the related thiol network in Caenorhabditis elegans.Redox biology · 2019Review
- Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems.Molecular nutrition & food research · 2019Article
- Circular Estimate Method (CEM) - a Simple Method to EstimateBiological procedures online · 2019Article
- Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients.Nutrients · 2018Review
- Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans.Metallomics : integrated biometal science · 2018Article
- A selenium species in cerebrospinal fluid predicts conversion to Alzheimer's dementia in persons with mild cognitive impairment.Alzheimer's research & therapy · 2017Article
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- Antagonistic Growth Effects of Mercury and Selenium in Caenorhabditis elegans Are Chemical-Species-Dependent and Do Not Depend on Internal Hg/Se Ratios.Environmental science & technology · 2016Article
- Assessment of selenium toxicity on the life cycle of Caenorhabditis elegans.Ecotoxicology (London, England) · 2014Article
- The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans.Neurotoxicology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Thioredoxin reductase-1 (TRXR-1) is the sole selenoprotein in C. elegans, and selenite is a substrate for thioredoxin reductase, so TRXR-1 may play a role in metabolism of selenium (Se) to toxic forms. To study the role of TRXR in Se toxicity, we cultured C. elegans with deletions of trxr-1, trxr-2, and both in axenic media with increasing concentrations of inorganic Se. Wild-type C. elegans cultured for 12 days in Se-deficient axenic media grow and reproduce equivalent to Se-supplemented media. Supplementation with 0-2 mM Se as selenite results in inverse, sigmoidal response curves with an LC50 of 0.20 mM Se, due to impaired growth rather than reproduction. Deletion of trxr-1, trxr-2 or both does not modulate growth or Se toxicity in C. elegans grown axenically, and (75)Se labeling showed that TRXR-1 arises from the trxr-1 gene and not from bacterial genes. Se response curves for selenide (LC50 0.23 mM Se) were identical to selenite, but selenate was 1/4(th) as toxic (LC50 0.95 mM Se) as selenite and not modulated by TRXR deletion. These nutritional and genetic studies in axenic media show that Se and TRXR are not essential for C. elegans, and that TRXR alone is not essential for metabolism of inorganic Se to toxic species.
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