ArticlePloS one2013
Downregulation of keratin 76 expression during oral carcinogenesis of human, hamster and mouse.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- A computational study of gene expression patterns in head and neck squamous cell carcinoma using TCGA data.Future science OA · 2024Article
- Article
- Unraveling the Keratin Expression in Oral Leukoplakia: A Scoping Review.International journal of molecular sciences · 2024Article
- PES1 is a biomarker of head and neck squamous cell carcinoma and is associated with the tumor microenvironment.Cancer medicine · 2023Article
- Identification of Biomarkers Associated with Cancerous Change in Oral Leukoplakia Based on Integrated Transcriptome Analysis.Journal of oncology · 2022Article
- Integrated analysis and identification of nine-gene signature associated to oral squamous cell carcinoma pathogenesis.3 Biotech · 2021Article
- Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma.Frontiers in oncology · 2020Review
- Multifaceted role of keratins in epithelial cell differentiation and transformation.Journal of biosciences · 2019Review
- Heterogeneity of the Head and Neck Squamous Cell Carcinoma Immune Landscape and Its Impact on Immunotherapy.Frontiers in cell and developmental biology · 2019Review
- Immunomodulatory role of Keratin 76 in oral and gastric cancer.Nature communications · 2018Article
- Article
- Keratin 76 is required for tight junction function and maintenance of the skin barrier.PLoS genetics · 2014Article
- Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.Nature communications · 2014Article
- The Hamster Model of Sequential Oral Carcinogenesis: An Update.In vivo (Athens, Greece)Review
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundKeratins are structural marker proteins with tissue specific expression; however, recent reports indicate their involvement in cancer progression. Previous study from our lab revealed deregulation of many genes related to structural molecular integrity including KRT76. Here we evaluate the role of KRT76 downregulation in oral precancer and cancer development.
methodsWe evaluated KRT76 expression by qRT-PCR in normal and tumor tissues of the oral cavity. We also analyzed K76 expression by immunohistochemistry in normal, oral precancerous lesion (OPL), oral squamous cell carcinoma (OSCC) and in hamster model of oral carcinogenesis. Further, functional implication of KRT76 loss was confirmed using KRT76-knockout (KO) mice.
resultsWe observed a strong association of reduced K76 expression with increased risk of OPL and OSCC development. The buccal epithelium of DMBA treated hamsters showed a similar trend. Oral cavity of KRT76-KO mice showed preneoplastic changes in the gingivobuccal epithelium while no pathological changes were observed in KRT76 negative tissues such as tongue.
conclusionThe present study demonstrates loss of KRT76 in oral carcinogenesis. The KRT76-KO mice data underlines the potential of KRT76 being an early event although this loss is not sufficient to drive the development of oral cancers. Thus, future studies to investigate the contributing role of KRT76 in light of other tumor driving events are warranted.
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