ArticlePloS one2013
Identification and characterization of a novel Shigella flexneri serotype Yv in China.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 50 citations in OpenAlex.
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- Robust Performance of Culture, qPCR, and Genomic Approaches for Shigella Serotyping in a Pediatric Surveillance Cohort.medRxiv : the preprint server for health sciences · 2026Article
- AnalyzingInfection and drug resistance · 2025Article
- Production of highly immunogenic and safe Triton X-100 produced bacterial ghost vaccine against Shigella flexneri 2b serotype.Gut pathogens · 2023Article
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- ShigaPass: anMicrobial genomics · 2023Article
- Identification of critical residues of O-antigen-modifying O-acetyltransferase B (OacB) of Shigella flexneri.BMC molecular and cell biology · 2022Article
- Phylogenomic Investigation of Increasing Fluoroquinolone Resistance among Belgian Cases of Shigellosis between 2013 and 2018 Indicates Both Travel-Related Imports and Domestic Circulation.Microorganisms · 2021Article
- Evaluation of Molecular Serotyping Assays for Shigella flexneri Directly on Stool Samples.Journal of clinical microbiology · 2021Article
- Influence of Shigella flexneri 2a O Antigen Acetylation on Its Bacteriophage Sf6 Receptor Activity and Bacterial Interaction with Human Cells.Journal of bacteriology · 2020Article
- Newly Emerged Serotype 1c ofGenes · 2020Article
- Shifting national surveillance of Shigella infections toward geno-serotyping by the development of a tailored Luminex assay and NGS workflow.MicrobiologyOpen · 2019Article
- Antimicrobial resistance and genetic characterization of Shigella spp. in Shanxi Province, China, during 2006-2016.BMC microbiology · 2019Article
- Plasmids of Shigella flexneri serotype 1c strain Y394 provide advantages to bacteria in the host.BMC microbiology · 2019Article
- PCR-Based Method for Shigella flexneri Serotyping: International Multicenter Validation.Journal of clinical microbiology · 2019Article
- SmallFrontiers in microbiology · 2019Article
- Extensive inter-strain diversity among clinical isolates ofGut pathogens · 2019Article
- Evaluation of a Culture-Dependent Algorithm and a Molecular Algorithm for Identification of Shigella spp., Escherichia coli, and Enteroinvasive E. coli.Journal of clinical microbiology · 2018Article
- Characterization and Genomic Analysis of SFPH2, a NovelFrontiers in microbiology · 2018Article
- Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shigella flexneri is the major cause of bacterial shigellosis in developing countries. S. flexneri is divided into at least 19 serotypes, the majority of which are modifications of the same basic O-antigen by glucosylation and/or O-acetylation of its sugar residues by phage encoded serotype-converting genes. Recently, a plasmid encoded phosphoethanolamine (PEtN) modification of the O-antigen has been reported, which is responsible for the presence of the MASF IV-1 determinant and results in conversion of traditional serotypes X, 4a and Y to novel serotypes Xv, 4av and Yv, respectively. In this study, we characterized 19 serotype Yv strains isolated in China. A variant of the O-antigen phosphoethanolamine transferase gene opt (formerly called lpt-O) carried by a pSFxv_2-like plasmid was found in serotype Yv strains, which specifies the phosphorylation pattern on the O-antigen of this serotype. For the majority of the O-antigen units, the PEtN modification occurs on Rha(III), while for a minority, modifications occur on both Rha(II) and Rha(III). Serotype-specific gene detection and PFGE analysis suggested that these serotype Yv isolates were originated from serotypes Y, Xv and 2a by acquisition of an opt-carrying plasmid and/or inactivation of serotype-specific gene gtrII or gtrX. These data, combined with those of serotypes Xv and 4av reported earlier, demonstrate that the plasmid-encoded PEtN modification is an important serotype conversion mechanism in S. flexneri, in addition to glucosylation and O-acetylation.
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