ArticlePloS one2013
Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Computational Model of Complex Calcium Dynamics: Store Operated CaCell biochemistry and biophysics · 2025Article
- Computational insights in cell physiology.Frontiers in systems biology · 2024Review
- Exercise Reduces Airway Smooth Muscle Contraction in Asthmatic Rats via Inhibition of IL-4 Secretion and Store-Operated CaAllergy, asthma & immunology research · 2023Article
- Inherent differences of small airway contraction and CaFrontiers in cell and developmental biology · 2023Article
- Characterizing spontaneous CaBiophysical journal · 2022Article
- A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers.The Journal of general physiology · 2022Article
- Airway smooth muscle and airway hyperresponsiveness in asthma: mechanisms of airway smooth muscle dysfunction.Minerva medica · 2022Article
- Comprehensive Simulation of CaInternational journal of molecular sciences · 2021Article
- High-affinity P2Y2 and low-affinity P2X7 receptor interaction modulates ATP-mediated calcium signaling in murine osteoblasts.PLoS computational biology · 2021Article
- Reciprocal Correlations of Inflammatory and Calcium Signaling in Asthma Pathogenesis.Advances in experimental medicine and biology · 2021Article
- Understanding doxorubicin associated calcium remodeling during triple-negative breast cancer treatment: anExploration of targeted anti-tumor therapy · 2021Article
- Three-Dimensional Model of Sub-Plasmalemmal CaFrontiers in immunology · 2021Article
- Cell shape regulates subcellular organelle location to control early CaScientific reports · 2020Article
- A mathematical model of calcium dynamics: Obesity and mitochondria-associated ER membranes.PLoS computational biology · 2019Article
- Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and CaThe Journal of allergy and clinical immunology · 2018Article
- A mathematical and computational model of the calcium dynamics in Caenorhabditis elegans ASH sensory neuron.PloS one · 2018Article
- Mathematical investigation of IPJournal of computational neuroscience · 2017Article
- The relative contributions of store-operated and voltage-gated CaThe Journal of physiology · 2017Article
- Store-operated calcium entry is required for sustained contraction and CaThe Journal of physiology · 2017Article
- A mathematical model of calcium dynamics in HSY cells.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Intracellular Ca(2+) dynamics of airway smooth muscle cells (ASMC) mediate ASMC contraction and proliferation, and thus play a key role in airway hyper-responsiveness (AHR) and remodelling in asthma. We evaluate the importance of store-operated Ca(2+) entry (SOCE) in these Ca(2+) dynamics by constructing a mathematical model of ASMC Ca(2+) signaling based on experimental data from lung slices. The model confirms that SOCE is elicited upon sufficient Ca(2+) depletion of the sarcoplasmic reticulum (SR), while receptor-operated [Ca(2+) entry (ROCE) is inhibited in such conditions. It also shows that SOCE can sustain agonist-induced Ca(2+) oscillations in the absence of other [Ca(2+) influx. SOCE up-regulation may thus contribute to AHR by increasing the Ca(2+) oscillation frequency that in turn regulates ASMC contraction. The model also provides an explanation for the failure of the SERCA pump blocker CPA to clamp the cytosolic Ca(2+) of ASMC in lung slices, by showing that CPA is unable to maintain the SR empty of Ca(2+). This prediction is confirmed by experimental data from mouse lung slices, and strongly suggests that CPA only partially inhibits SERCA in ASMC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.