SynthesisPloS one2013
Is obstructive sleep apnea associated with cardiovascular and all-cause mortality?
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- The impact of body mass index on mortality in COPD: an updated dose-response meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- The clinical characteristic of catathrenia: a new look at an old issue-a systematic review of existing literature.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Triglyceride-glucose index and obstructive sleep apnea: a systematic review and meta-analysis.Lipids in health and disease · 2024Pooled it
- What is the association between secondhand smoke (SHS) and possible obstructive sleep apnea: a meta-analysis.Environmental health : a global access science source · 2022Pooled it
- An umbrella review of systematic reviews and meta-analyses of observational investigations of obstructive sleep apnea and health outcomes.Sleep & breathing = Schlaf & Atmung · 2022Pooled it
- Association of obstructive sleep apnoea with the risk of vascular outcomes and all-cause mortality: a meta-analysis.BMJ open · 2017Pooled it
- Meta-analysis of all-cause and cardiovascular mortality in obstructive sleep apnea with or without continuous positive airway pressure treatment.Sleep & breathing = Schlaf & Atmung · 2017Pooled it
- Obstructive sleep apnoea and risks of all-cause mortality: preliminary evidence from prospective cohort studies.Sleep & breathing = Schlaf & Atmung · 2016Pooled it
- Who Really Benefits from CPAP? Disease Severity, Response Quality, and Long-Term Survival in Obstructive Sleep Apnea.Advances in respiratory medicine · 2026Article
- Association of obstructive sleep apnoea with exercise capacity and mortality in a population-based study: results of SHIP-TREND.ERJ open research · 2026Article
- Obstructive sleep apnea and functional hearing loss over 8 years: results from the National Health and Aging Trends Study.American journal of epidemiology · 2026Article
- Impact of obstructive sleep apnea and comorbid insomnia on all-cause mortality: a prospective cohort study of 2401 patients with 6-year follow-up.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Oral mucosal health in acromegaly: clinical insights and metabolic associations.BMC oral health · 2025Article
- Association between triglyceride glucose index related parameters and obstructive sleep apnea hypopnea syndrome in a cross sectional study.Scientific reports · 2025Article
- Therapeutic Management in Patients with Chronic Obstructive Pulmonary Disease Who Are Overweight or Obese: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Article
- Exploring the Association Between Triglyceride-Glucose Indices and Their Derivatives With Obstructive Sleep Apnea: Insights From the National Health and Nutrition Examination Survey.Nature and science of sleep · 2025Article
- The readability of online patient education materials on maxillomandibular advancement surgery.Sleep & breathing = Schlaf & Atmung · 2024Article
- Apnea-hypopnea index and the polysomnographic risk factors for predicting 5- to 8-year mortality in patients with OSA.Sleep & breathing = Schlaf & Atmung · 2024Article
- Obstructive sleep apnea and vitamin D level: Has the dust settled?The clinical respiratory journal · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies have reported inconsistent findings regarding the association between obstructive sleep apnea (OSA) and future risks of cardiovascular and all-cause mortality. We conducted a meta-analysis to investigate whether OSA is an independent predictor for future cardiovascular and all-cause mortality using prospective observational studies.
methodsElectronic literature databases (Medline and Embase) were searched for prospective observational studies published prior to December 2012. Only observational studies that assessed baseline OSA and future risk of cardiovascular and all-cause mortality were selected. Pooled hazard risk (HR) and corresponding 95% confidence intervals (CI) were calculated for categorical risk estimates. Subgroup analyses were based on the severity of OSA.
resultsSix studies with 11932 patients were identified and analyzed, with 239 reporting cardiovascular mortality, and 1397 all-cause mortality. Pooled HR of all-cause mortality was 1.19 (95% CI, 1.00 to 1.41) for moderate OSA and 1.90 (95% CI, 1.29 to 2.81) for severe OSA. Pooled HR of cardiovascular mortality was 1.40 (95% CI, 0.77 to 2.53) for moderate OSA and 2.65 (95% CI, 1.82 to 3.85) for severe OSA. There were no differences in cardiovascular mortality in continuous positive airway pressure (CPAP) treatment compared with healthy subjects (HR 0.82; 95% CI, 0.50 to 1.33).
conclusionsSevere OSA is a strong independent predictor for future cardiovascular and all-cause mortality. CPAP treatment was associated with decrease cardiovascular mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.