ArticlePloS one2013
Gap junctions are essential for generating the correlated spike activity of neighboring retinal ganglion cells.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 64 citations in OpenAlex.
- Retinal Electrical Synapses Prime Neighbor Cells to Amplify Looming Related Threat Signals and Support Escape Behavior.Research square · 2026Article
- Domain-like patterning of dendritic asymmetry and orientation defined by gap junctions in the mouse retina.iScience · 2025Article
- The structure, function, and distribution of gap junctions in the retina: Life cycle in health and disease.Journal of cell communication and signaling · 2025Review
- Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array.iScience · 2024Article
- Extrinsic and Intrinsic Factors Determine Expression Levels of Gap Junction-Forming Connexins in the Mammalian Retina.Biomolecules · 2023Review
- On the Functional Role of Gamma Synchronization in the Retinogeniculate System of the Cat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Graphene-based microfluidic perforated microelectrode arrays for retinal electrophysiological studies.Lab on a chip · 2023Article
- Serotonin is a gap junction-permeable neuronal tracer in the mouse retina.Frontiers in ophthalmology · 2023Article
- Biotin-cGMP and -cAMP are able to permeate through the gap junctions of some amacrine cells in the mouse retina despite their large size.Frontiers in ophthalmology · 2023Article
- Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation.Frontiers in cellular neuroscience · 2022Article
- The role of gap junctions in cell death and neuromodulation in the retina.Neural regeneration research · 2021Review
- Article
- On the potential role of lateral connectivity in retinal anticipation.Journal of mathematical neuroscience · 2021Article
- Feedback from retinal ganglion cells to the inner retina.PloS one · 2021Article
- PTEN Expression Regulates Gap Junction Connectivity in the Retina.Frontiers in neuroanatomy · 2021Article
- The Effect of Low-Dose Atropine on Alpha Ganglion Cell Signaling in the Mouse Retina.Frontiers in cellular neuroscience · 2021Article
- Early visual motion experience shapes the gap junction connections among direction selective ganglion cells.PLoS biology · 2020Article
- Article
- Electrical Coupling of Heterotypic Ganglion Cells in the Mammalian Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A Neural Network Model With Gap Junction for Topological Detection.Frontiers in computational neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Neurons throughout the brain show spike activity that is temporally correlated to that expressed by their neighbors, yet the generating mechanism(s) remains unclear. In the retina, ganglion cells (GCs) show robust, concerted spiking that shapes the information transmitted to central targets. Here we report the synaptic circuits responsible for generating the different types of concerted spiking of GC neighbors in the mouse retina. The most precise concerted spiking was generated by reciprocal electrical coupling of GC neighbors via gap junctions, whereas indirect electrical coupling to a common cohort of amacrine cells generated the correlated activity with medium precision. In contrast, the correlated spiking with the lowest temporal precision was produced by shared synaptic inputs carrying photoreceptor noise. Overall, our results demonstrate that different synaptic circuits generate the discrete types of GC correlated activity. Moreover, our findings expand our understanding of the roles of gap junctions in the retina, showing that they are essential for generating all forms of concerted GC activity transmitted to central brain targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.