ArticlePloS one2013
Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Examining electroencephalogram signatures of people with multiple sclerosis using a nonlinear dynamics approach: a systematic review and bibliographic analysis.Frontiers in computational neuroscience · 2023Pooled it
- Cognitive rehabilitation and mindfulness in multiple sclerosis (REMIND-MS): a study protocol for a randomised controlled trial.BMC neurology · 2017Trial
- Functional Connectivity at Rest and During Cognitive Processing in Multiple Sclerosis: A Pilot Magnetoencephalography Study and Systematic Review.Brain sciences · 2026Article
- Decoding Visual Pathway Dysfunction with SERF-MEG: A Study in Patients with Optic Neuropathy.Bioengineering (Basel, Switzerland) · 2026Article
- Individual differences in conditioned pain modulation are associated with alpha oscillations.Pain · 2026Article
- Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Graph-Based Analysis of Brain Connectivity in Multiple Sclerosis Using Functional MRI: A Systematic Review.Brain sciences · 2023Review
- Microstates in multiple sclerosis: an electrophysiological signature of altered large-scale networks functioning?Brain communications · 2023Article
- Multistage classification identifies altered cortical phase- and amplitude-coupling in Multiple Sclerosis.NeuroImage · 2022Article
- Network alterations underlying anxiety symptoms in early multiple sclerosis.Journal of neuroinflammation · 2022Article
- Functional brain network organization measured with magnetoencephalography predicts cognitive decline in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Brain dysconnectivity relates to disability and cognitive impairment in multiple sclerosis.Human brain mapping · 2021Article
- Abnormal alpha band power in the dynamic pain connectome is a marker of chronic pain with a neuropathic component.NeuroImage. Clinical · 2020Article
- Energy landscape of resting magnetoencephalography reveals fronto-parietal network impairments in epilepsy.Network neuroscience (Cambridge, Mass.) · 2020Article
- Cognitive Impairment and Brain Reorganization in MS: Underlying Mechanisms and the Role of Neurorehabilitation.Frontiers in neurology · 2020Review
- Modeling Resilience to Damage in Multiple Sclerosis: Plasticity Meets Connectivity.International journal of molecular sciences · 2019Review
- Resting-state MEG measurement of functional activation as a biomarker for cognitive decline in MS.Multiple sclerosis (Houndmills, Basingstoke, England) · 2019Article
- Neurovascular Coupling During Visual Stimulation in Multiple Sclerosis: A MEG-fMRI Study.Neuroscience · 2019Article
- Central Neuropathic Pain and Profiles of Quantitative Electroencephalography in Multiple Sclerosis Patients.Frontiers in neurology · 2019Article
- Explaining the heterogeneity of functional connectivity findings in multiple sclerosis: An empirically informed modeling study.Human brain mapping · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relation between pathological findings and clinical and cognitive decline in Multiple Sclerosis remains unclear. Here, we tested the hypothesis that altered functional connectivity could provide a missing link between structural findings, such as thalamic atrophy and white matter lesion load, and clinical and cognitive dysfunction. Resting-state magnetoencephalography recordings from 21 MS patients and 17 gender- and age matched controls were projected onto atlas-based regions-of-interest using beamforming. Average functional connectivity was computed for each ROI and literature-based resting-state networks using the phase-lag index. Structural measures of whole brain and thalamic atrophy and lesion load were estimated from MRI scans. Global analyses showed lower functional connectivity in the alpha2 band and higher functional connectivity in the beta band in patients with Multiple Sclerosis. Additionally, alpha2 band functional connectivity was lower for the patients in two resting-state networks, namely the default mode network and the visual network. Higher beta band functional connectivity was found in the default mode network and in the temporo-parietal network. Lower alpha2 band functional connectivity in the visual network was related to lower thalamic volumes. Beta band functional connectivity correlated positively with disability scores, most prominently in the default mode network, and correlated negatively with cognitive performance in this network. These findings illustrate the relationship between thalamic atrophy, altered functional connectivity and clinical and cognitive dysfunction in MS, which could serve as a bridge to understand how neurodegeneration is associated with altered functional connectivity and subsequently clinical and cognitive decline.
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Registered trials
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