ArticlePloS one2013
MHC class IIB exon 2 polymorphism in the Grey partridge (Perdix perdix) is shaped by selection, recombination and gene conversion.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- Genetic variation at innate and adaptive immune genes - contrasting patterns of differentiation and local adaptation in a wild gull.Heredity · 2023Article
- A Highly Complex, MHC-Linked, 350 Million-Year-Old Shark Nonclassical Class I Lineage.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Lack of evidence for selection favouring MHC haplotypes that combine high functional diversity.Heredity · 2018Article
- Very high MHC Class IIB diversity without spatial differentiation in the mediterranean population of greater Flamingos.BMC evolutionary biology · 2017Article
- Polymorphism in the major histocompatibility complex (MHC class II B) genes of the Rufous-backed Bunting (PeerJ · 2017Article
- Mate choice for major histocompatibility complex complementarity in a strictly monogamous bird, the grey partridge (Frontiers in zoology · 2017Article
- Microsatellite and major histocompatibility complex variation in an endangered rattlesnake, the Eastern Massasauga (Sistrurus catenatus).Ecology and evolution · 2016Article
- New data from basal Australian songbird lineages show that complex structure of MHC class II β genes has early evolutionary origins within passerines.BMC evolutionary biology · 2016Article
- Contrasting evolutionary histories of MHC class I and class II loci in grouse--effects of selection and gene conversion.Heredity · 2016Article
- Isolation and characterization of major histocompatibility complex class II B genes in cranes.Immunogenetics · 2015Article
- Characterization of a non-classical MHC class II gene in the vulnerable Chinese egret (Egretta eulophotes).Immunogenetics · 2015Article
- Genetic variation of the major histocompatibility complex (MHC class II B gene) in the threatened Hume's pheasant, Syrmaticus humiae.PloS one · 2015Article
- Extraordinary MHC class II B diversity in a non-passerine, wild bird: the Eurasian Coot Fulica atra (Aves: Rallidae).Ecology and evolution · 2014Article
- Stepwise threshold clustering: a new method for genotyping MHC loci using next-generation sequencing technology.PloS one · 2014Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among bird species, the most studied major histocompatibility complex (MHC) is the chicken MHC. Although the number of studies on MHC in free-ranging species is increasing, the knowledge on MHC variation in species closely related to chicken is required to understand the peculiarities of bird MHC evolution. Here we describe the variation of MHC class IIB (MHCIIB) exon 2 in a population of the Grey partridge (Perdix perdix), a species of high conservation concern throughout Europe and an emerging galliform model in studies of sexual selection. We found 12 alleles in 108 individuals, but in comparison to other birds surprisingly many sites show signatures of historical positive selection. Individuals displayed between two to four alleles both on genomic and complementary DNA, suggesting the presence of two functional MHCIIB loci. Recombination and gene conversion appear to be involved in generating MHCIIB diversity in the Grey partridge; two recombination breakpoints and several gene conversion events were detected. In phylogenetic analysis of galliform MHCIIB, the Grey partridge alleles do not cluster together, but are scattered through the tree instead. Thus, our results indicate that the Grey partridge MHCIIB is comparable to most other galliforms in terms of copy number and population polymorphism.
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