ArticlePloS one2013
Abnormal pre-attentive arousal in young children with autism spectrum disorder contributes to their atypical auditory behavior: an ERP study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2016Trial
- Attention-Dependent but not Pre-attentive Neural Markers of Auditory Change Process are Atypical in Adults With Autism Spectrum Conditions.Journal of autism and developmental disorders · 2025Article
- Auditory evoked neuromagnetic response latency is associated with language ability in preschoolers with an elevated likelihood of intellectual or developmental disability.Frontiers in integrative neuroscience · 2025Article
- Article
- Elevated and accelerated: Locus coeruleus activity and visual search abilities in autistic children.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Habituation of auditory responses in young autistic and neurotypical children.Autism research : official journal of the International Society for Autism Research · 2023Article
- Auditory evoked potentials in adolescents with autism: An investigation of brain development, intellectual impairment, and neural encoding.Autism research : official journal of the International Society for Autism Research · 2023Article
- Neurophysiological measures of auditory sensory processing are associated with adaptive behavior in children with Autism Spectrum Disorder.Journal of neurodevelopmental disorders · 2023Article
- Pupil-Linked Arousal Response Reveals Aberrant Attention Regulation among Children with Autism Spectrum Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Looking for consistency in an uncertain world: test-retest reliability of neurophysiological and behavioral readouts in autism.Journal of neurodevelopmental disorders · 2021Article
- 40-Hz Auditory Steady-State Response (ASSR) as a Biomarker of Genetic Defects in theInternational journal of molecular sciences · 2021Article
- The Deficit of Multimodal Perception of Congruent and Non-Congruent Fearful Expressions in Patients with Schizophrenia: The ERP Study.Brain sciences · 2021Article
- Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD.Molecular autism · 2020Article
- Impaired P1 Habituation and Mismatch Negativity in Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2020Article
- Effects of Age and Type of Stimulus on the Cortical Auditory Evoked Potential in Healthy Malaysian Children.Journal of audiology & otology · 2020Article
- Auditory Attentional Disengagement in Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2019Article
- Thermal Perceptual Thresholds are typical in Autism Spectrum Disorder but Strongly Related to Intra-individual Response Variability.Scientific reports · 2019Article
- Sensory processing in autism spectrum disorders and Fragile X syndrome-From the clinic to animal models.Neuroscience and biobehavioral reviews · 2017Review
- BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Atypical speech versus non-speech detection and discrimination in 4- to 6- yr old children with autism spectrum disorder: An ERP study.PloS one · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auditory sensory modulation difficulties and problems with automatic re-orienting to sound are well documented in autism spectrum disorders (ASD). Abnormal preattentive arousal processes may contribute to these deficits. In this study, we investigated components of the cortical auditory evoked potential (CAEP) reflecting preattentive arousal in children with ASD and typically developing (TD) children aged 3-8 years. Pairs of clicks ('S1' and 'S2') separated by a 1 sec S1-S2 interstimulus interval (ISI) and much longer (8-10 sec) S1-S1 ISIs were presented monaurally to either the left or right ear. In TD children, the P50, P100 and N1c CAEP components were strongly influenced by temporal novelty of clicks and were much greater in response to the S1 than the S2 click. Irrespective of the stimulation side, the 'tangential' P100 component was rightward lateralized in TD children, whereas the 'radial' N1c component had higher amplitude contralaterally to the stimulated ear. Compared to the TD children, children with ASD demonstrated 1) reduced amplitude of the P100 component under the condition of temporal novelty (S1) and 2) an attenuated P100 repetition suppression effect. The abnormalities were lateralized and depended on the presentation side. They were evident in the case of the left but not the right ear stimulation. The P100 abnormalities in ASD correlated with the degree of developmental delay and with the severity of auditory sensory modulation difficulties observed in early life. The results suggest that some rightward-lateralized brain networks that are crucially important for arousal and attention re-orienting are compromised in children with ASD and that this deficit contributes to sensory modulation difficulties and possibly even other behavioral deficits in ASD.
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