Evidence map›Paper›PMID 23935894›Full record

ArticlePloS one2013

Molecular and functional characterization of odorant-binding protein genes in an invasive vector mosquito, Aedes albopictus.

Yuhua Deng, Hui Yan, Jinbao Gu, Jiabao Xu, Kun Wu, Zhijian Tu, Anthony A James, Xiaoguang Chen

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Multi-stage insecticide potentials ofCurrent research in parasitology & vector-borne diseases · 2026
    Article
  4. Article
  5. Review
  6. Olfactory systems across mosquito species.Cell and tissue research · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yuhua DengKey Laboratory of Prevention and Control of Emerging Infectious Diseases of Guangdong Higher Education Institutes, School of Public Health and Tropical Medicine, Southern Medical University, Guangdong, PR China.
Hui Yan
Jinbao Gu
Jiabao Xu
Kun Wu
Zhijian Tu
Anthony A James
Xiaoguang Chen
Southern Medical University · CNUniversity of California, Irvine · USVirginia Tech · US

Funding

Impacts of Urbanization on Vector Biology and Transmission of Dengue in ChinaR01AI083202 · NIAID · SOUTHERN MEDICAL UNIVERSITY · PI CHEN, XIAOGUANG · 2010 to 2013
$413k
NIAID NIH HHS R01 AI083202
6 · The paper itself

Abstract

Aedes albopictus is a major vector of dengue and Chikungunya viruses. Olfaction plays a vital role in guiding mosquito behaviors and contributes to their ability to transmit pathogens. Odorant-binding proteins (OBPs) are abundant in insect olfactory tissues and involved in the first step of odorant reception. While comprehensive descriptions are available of OBPs from Aedes aegypti, Culex quinquefasciatus and Anopheles gambiae, only a few genes from Ae. albopictus have been reported. In this study, twenty-one putative AalbOBP genes were cloned using their homologues in Ae. aegypti to query an Ae. albopictus partial genome sequence. Two antenna-specific OBPs, AalbOBP37 and AalbOBP39, display a remarkable similarity in their overall folding and binding pockets, according to molecular modeling. Binding affinity assays indicated that AalbOBP37 and AalbOBP39 had overlapping ligand affinities and are affected in different pH condition. Electroantennagrams (EAG) and behavioral tests show that these two genes were involved in olfactory reception. An improved understanding of the Ae. albopictus OBPs is expected to contribute to the development of more efficient and environmentally-friendly mosquito control strategies.

Indexed as

Introduced SpeciesAedesAmino Acid SequenceAnimalsArthropod AntennaeBehavior, AnimalCloning, MolecularFemaleGene Expression ProfilingGene Expression RegulationGene Knockdown TechniquesGenes, InsectInsect ProteinsInsect VectorsModels, MolecularMolecular Sequence DataInsect Proteinsodorant-binding proteinReceptors, OdorantRNA, Double-Stranded

Identifiers

PMID23935894
PMCPMC3720860
OpenAlexW2056601761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.