ArticlePloS one2013
Genetic polymorphism of human Y chromosome and risk factors for cardiovascular diseases: a study in WOBASZ cohort.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Limited Effect of Y Chromosome Variation on Coronary Artery Disease and Mortality in UK Biobank-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Review
- Y-Chromosome Genetic Analysis of Modern Polish Population.Frontiers in genetics · 2020Article
- The Challenges of Chromosome Y Analysis and the Implications for Chronic Kidney Disease.Frontiers in genetics · 2019Review
- Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence.Atherosclerosis · 2018Article
- The Y chromosome: a blueprint for men's health?European journal of human genetics : EJHG · 2017Review
- Chromosome Y genetic variants: impact in animal models and on human disease.Physiological genomics · 2015Review
- A note of caution on the diagnosis of Martin-Probst syndrome by the detection of the p.D59G mutation in the RAB40AL gene.European journal of pediatrics · 2015Article
- A study in Polish patients with cardiomyopathy emphasizes pathogenicity of phospholamban (PLN) mutations at amino acid position 9 and low penetrance of heterozygous null PLN mutations.BMC medical genetics · 2015Article
- Dietary antioxidant capacity of the patients with cardiovascular disease in a cross-sectional study.Nutrition journal · 2015Article
- Y genetic variation and phenotypic diversity in health and disease.Biology of sex differences · 2015Article
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5 authors.
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Abstract
Genetic variants of Y chromosome predispose to hypertension in rodents, whereas in humans the evidence is conflicting. Our purpose was to study the distribution of a panel of Y chromosome markers in a cohort from a cross-sectional population-based study on the prevalence of cardiovascular risk factors in Poland (WOBASZ study). The HindIII, YAP Y chromosome variants, previously shown to influence blood pressure, lipid traits or height, as well as SNPs defining main Y chromosome haplogroups, were typed in 3026, 2783 and 2652 samples, respectively. In addition, 4 subgroups (N~100 each) representing extremes of LDL concentration or blood pressure (BP) were typed for a panel of 17 STRs. The HindIII and YAP polymorphism were not associated with any of the studied traits. Analysis of the haplogroup distribution showed an association between higher HDL level and hg I-M170 (P = 0.02), higher LDL level and hg F*(xI-M170, J2-M172, K-M9) (P = 0.03) and lower BMI and hg N3-Tat (P = 0.04). Analysis of STRs did not show statistically significant differences. Since all these associations lost statistical significance after Bonferroni correction, we conclude that a major role of Y chromosome genetic variation (defined by HindIII, YAP or main Y chromosome haplogroups) in determining cardiovascular risk in Poles is unlikely.
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