ArticlePloS one2013
Development and evaluation of an algorithm for the computer-assisted segmentation of the human hypothalamus on 7-Tesla magnetic resonance images.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.PloS one · 2015Trial
- Prenatal maternal stress is associated with alterations in the structural integrity of the hypothalamic-pituitary-gonadal axis 20 years later: Project Ice Storm.Human reproduction (Oxford, England) · 2026Article
- Hypothalamus volumes and mental health in children and adolescents.Frontiers in neuroscience · 2026Article
- Changes in hypothalamic subunits volume and their association with metabolic parameters and gastrointestinal appetite-regulating hormones following bariatric surgery.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Manual segmentation of the paraventricular nucleus of the hypothalamus and the dorsal and ventral bed nucleus of stria terminalis using multimodal 7 Tesla structural MRI: probabilistic atlases for a stress-control triad.Brain structure & function · 2024Article
- FastSurfer-HypVINN: Automated sub-segmentation of the hypothalamus and adjacent structures on high-resolutional brain MRI.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Hypothalamic volume is associated with body mass index.NeuroImage. Clinical · 2023Article
- Article
- Oral contraceptive use is associated with smaller hypothalamic and pituitary gland volumes in healthy women: A structural MRI study.PloS one · 2021Article
- Clinical Implication of Individually Tailored Segmentation Method for Distorted Hypothalamus in Craniopharyngioma.Frontiers in endocrinology · 2021Article
- Automated diffusion-based parcellation of the hypothalamus reveals subunit-specific associations with obesity.Scientific reports · 2020Article
- A high-resolution in vivo magnetic resonance imaging atlas of the human hypothalamic region.Scientific data · 2020Article
- Morphofunctional Alterations of the Hypothalamus and Social Behavior in Autism Spectrum Disorders.Brain sciences · 2020Review
- Higher body mass index is linked to altered hypothalamic microstructure.Scientific reports · 2019Article
- Visualizing the Human Subcortex Using Ultra-high Field Magnetic Resonance Imaging.Brain topography · 2018Review
- Article
- Intensity standardisation of 7T MR images for intensity-based segmentation of the human hypothalamus.PloS one · 2017Article
- Brain-heart interactions: challenges and opportunities with functional magnetic resonance imaging at ultra-high field.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Review
- Lateral-Medial Dissociation in Orbitofrontal Cortex-Hypothalamus Connectivity.Frontiers in human neuroscience · 2016Article
- Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia.Journal of neurology · 2015Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post mortem studies have shown volume changes of the hypothalamus in psychiatric patients. With 7T magnetic resonance imaging this effect can now be investigated in vivo in detail. To benefit from the sub-millimeter resolution requires an improved segmentation procedure. The traditional anatomical landmarks of the hypothalamus were refined using 7T T1-weighted magnetic resonance images. A detailed segmentation algorithm (unilateral hypothalamus) was developed for colour-coded, histogram-matched images, and evaluated in a sample of 10 subjects. Test-retest and inter-rater reliabilities were estimated in terms of intraclass-correlation coefficients (ICC) and Dice's coefficient (DC). The computer-assisted segmentation algorithm ensured test-retest reliabilities of ICC≥.97 (DC≥96.8) and inter-rater reliabilities of ICC≥.94 (DC = 95.2). There were no significant volume differences between the segmentation runs, raters, and hemispheres. The estimated volumes of the hypothalamus lie within the range of previous histological and neuroimaging results. We present a computer-assisted algorithm for the manual segmentation of the human hypothalamus using T1-weighted 7T magnetic resonance imaging. Providing very high test-retest and inter-rater reliabilities, it outperforms former procedures established at 1.5T and 3T magnetic resonance images and thus can serve as a gold standard for future automated procedures.
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