ArticleMicrofluidics and nanofluidics2013
Controlled dispensing and mixing of pico- to nanoliter volumes using on-demand droplet-based microfluidics.
Article in Microfluidics and nanofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Coupling of droplet-on-demand microfluidcs with ESI/MS to study single-cell catalysis.RSC advances · 2024Article
- Flexible Toolbox of High-Precision Microfluidic Modules for Versatile Droplet-Based Applications.Micromachines · 2024Article
- Programmable Control of Nanoliter Droplet Arrays using Membrane Displacement Traps.Advanced materials technologies · 2023Article
- Faster, better, and cheaper: harnessing microfluidics and mass spectrometry for biotechnology.RSC chemical biology · 2021Review
- Mixing characterization of binary-coalesced droplets in microchannels using deep neural network.Biomicrofluidics · 2020Article
- A programmable microfluidic platform for multisample injection, discretization, and droplet manipulation.Biomicrofluidics · 2020Article
- Microfluidic on-demand droplet generation, storage, retrieval, and merging for single-cell pairing.Lab on a chip · 2019Article
- Active or Passive On-Demand Droplet Merging in a Microfluidic Valve-Based Trap.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2018Article
- Study of flow behaviors of droplet merging and splitting in microchannels using Micro-PIV measurement.Microfluidics and nanofluidics · 2017Article
- Mass spectrometry-based monitoring of millisecond protein-ligand binding dynamics using an automated microfluidic platform.Lab on a chip · 2016Article
- On-demand generation and mixing of liquid-in-gas slugs with digitally-programmable composition and size.Journal of micromechanics and microengineering : structures, devices, and systems · 2015Article
- Droplet electrospray ionization mass spectrometry for high throughput screening for enzyme inhibitors.Analytical chemistry · 2014Article
- Pneumatic microvalve-based hydrodynamic sample injection for high-throughput, quantitative zone electrophoresis in capillaries.Analytical chemistry · 2014Article
- Micro total analysis systems: fundamental advances and biological applications.Analytical chemistry · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We present an integrated droplet-on-demand microfluidic platform for dispensing, mixing, incubating, extracting and analyzing by mass spectrometry pico- to nanoliter-sized droplets. All of the functional components are successfully integrated for the first time into a monolithic microdevice. Droplet generation is accomplished using computer-controlled pneumatic valves. Controlled actuation of valves for different aqueous streams enables accurate dosing and rapid mixing of reagents within droplets in either the droplet generation area or in a region of widening channel cross-section. Following incubation, which takes place as droplets travel in the oil stream, the droplet contents are extracted to an aqueous channel for subsequent ionization at an integrated nanoelectrospray emitter. Using the integrated platform, rapid enzymatic digestions of a model protein were carried out in droplets and detected on-line by nanoelectrospray ionization mass spectrometry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.