ArticlePLoS genetics2013
Recombination dynamics of a human Y-chromosomal palindrome: rapid GC-biased gene conversion, multi-kilobase conversion tracts, and rare inversions.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Estimating Gene Conversion Tract Length and Rate From PacBio HiFi Data.Molecular biology and evolution · 2025Article
- Transcript Isoform Diversity of Y Chromosome Ampliconic Genes of Great Apes Uncovered Using Long Reads and Telomere-to-Telomere Reference Genome Assemblies.bioRxiv : the preprint server for biology · 2024Article
- High incidence of AZF duplications in clan-structured Iranian populations detected through Y chromosome sequencing read depth analysis.Scientific reports · 2023Article
- Characterizing the evolution and phenotypic impact of ampliconic Y chromosome regions.Nature communications · 2023Article
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- Article
- New insights into the evolution of human Y chromosome palindromes through mutation and gene conversion.Human molecular genetics · 2021Article
- GC-biased gene conversion in X-chromosome palindromes conserved in human, chimpanzee, and rhesus macaque.G3 (Bethesda, Md.) · 2021Article
- Article
- Assembly of the threespine stickleback Y chromosome reveals convergent signatures of sex chromosome evolution.Genome biology · 2020Article
- Large X-Linked Palindromes Undergo Arm-to-Arm Gene Conversion across Mus Lineages.Molecular biology and evolution · 2020Article
- Ampliconic Genes on the Great Ape Y Chromosomes: Rapid Evolution of Copy Number but Conservation of Expression Levels.Genome biology and evolution · 2020Article
- Evolutionary and functional impact of common polymorphic inversions in the human genome.Nature communications · 2019Article
- Selection Has Countered High Mutability to Preserve the Ancestral Copy Number of Y Chromosome Amplicons in Diverse Human Lineages.American journal of human genetics · 2018Article
- Copy number variation arising from gene conversion on the human Y chromosome.Human genetics · 2018Article
- Human Y-chromosome variation in the genome-sequencing era.Nature reviews. Genetics · 2017Review
- Analysis of 62 hybrid assembled human Y chromosomes exposes rapid structural changes and high rates of gene conversion.PLoS genetics · 2017Article
- The Y chromosomes of the great apes.Human genetics · 2017Review
- Y chromosome palindromes and gene conversion.Human genetics · 2017Review
- Understanding the Genomic Structure of Copy-Number Variation of the Low-Affinity Fcγ Receptor Region Allows Confirmation of the Association of FCGR3B Deletion with Rheumatoid Arthritis.Human mutation · 2017Article
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5 authors.
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Abstract
The male-specific region of the human Y chromosome (MSY) includes eight large inverted repeats (palindromes) in which arm-to-arm similarity exceeds 99.9%, due to gene conversion activity. Here, we studied one of these palindromes, P6, in order to illuminate the dynamics of the gene conversion process. We genotyped ten paralogous sequence variants (PSVs) within the arms of P6 in 378 Y chromosomes whose evolutionary relationships within the SNP-defined Y phylogeny are known. This allowed the identification of 146 historical gene conversion events involving individual PSVs, occurring at a rate of 2.9-8.4×10(-4) events per generation. A consideration of the nature of nucleotide change and the ancestral state of each PSV showed that the conversion process was significantly biased towards the fixation of G or C nucleotides (GC-biased), and also towards the ancestral state. Determination of haplotypes by long-PCR allowed likely co-conversion of PSVs to be identified, and suggested that conversion tract lengths are large, with a mean of 2068 bp, and a maximum in excess of 9 kb. Despite the frequent formation of recombination intermediates implied by the rapid observed gene conversion activity, resolution via crossover is rare: only three inversions within P6 were detected in the sample. An analysis of chimpanzee and gorilla P6 orthologs showed that the ancestral state bias has existed in all three species, and comparison of human and chimpanzee sequences with the gorilla outgroup confirmed that GC bias of the conversion process has apparently been active in both the human and chimpanzee lineages.
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