ArticlePLoS computational biology2013
Spatial stochastic dynamics enable robust cell polarization.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Information bounds on the accuracy of cell polarization.PloS one · 2025Article
- CellDynaMo-stochastic reaction-diffusion-dynamics model: Application to search-and-capture process of mitotic spindle assembly.PLoS computational biology · 2022Article
- A positive feedback loop involving the Spa2 SHD domain contributes to focal polarization.PloS one · 2022Article
- An arbitrary Lagrangian Eulerian smoothed particle hydrodynamics (ALE-SPH) method with a boundary volume fraction formulation for fluid-structure interaction.Engineering analysis with boundary elements · 2021Article
- A multiscale compartment-based model of stochastic gene regulatory networks using hitting-time analysis.The Journal of chemical physics · 2021Article
- Type V myosin focuses the polarisome and shapes the tip of yeast cells.The Journal of cell biology · 2021Article
- Coordinating cell polarization and morphogenesis through mechanical feedback.PLoS computational biology · 2021Article
- Four different mechanisms for switching cell polarity.PLoS computational biology · 2021Article
- Mechanistic insights into actin-driven polarity site movement in yeast.Molecular biology of the cell · 2020Article
- Hierarchical algorithm for the reaction-diffusion master equation.The Journal of chemical physics · 2020Article
- Smart computational exploration of stochastic gene regulatory network models using human-in-the-loop semi-supervised learning.Bioinformatics (Oxford, England) · 2019Article
- A 3D Multiscale Model to Explore the Role of EGFR Overexpression in Tumourigenesis.Bulletin of mathematical biology · 2019Article
- The effect of cell geometry on polarization in budding yeast.PLoS computational biology · 2018Article
- Parameter uncertainty quantification using surrogate models applied to a spatial model of yeast mating polarization.PLoS computational biology · 2018Article
- Mesoscopic-microscopic spatial stochastic simulation with automatic system partitioning.The Journal of chemical physics · 2017Article
- Beyond the Michaelis-Menten equation: Accurate and efficient estimation of enzyme kinetic parameters.Scientific reports · 2017Article
- Reaction rates for reaction-diffusion kinetics on unstructured meshes.The Journal of chemical physics · 2017Article
- A framework for discrete stochastic simulation on 3D moving boundary domains.The Journal of chemical physics · 2016Article
- Macromolecular Crowding Regulates the Gene Expression Profile by Limiting Diffusion.PLoS computational biology · 2016Article
- GillesPy: A Python Package for Stochastic Model Building and Simulation.IEEE life sciences letters · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Although cell polarity is an essential feature of living cells, it is far from being well-understood. Using a combination of computational modeling and biological experiments we closely examine an important prototype of cell polarity: the pheromone-induced formation of the yeast polarisome. Focusing on the role of noise and spatial heterogeneity, we develop and investigate two mechanistic spatial models of polarisome formation, one deterministic and the other stochastic, and compare the contrasting predictions of these two models against experimental phenotypes of wild-type and mutant cells. We find that the stochastic model can more robustly reproduce two fundamental characteristics observed in wild-type cells: a highly polarized phenotype via a mechanism that we refer to as spatial stochastic amplification, and the ability of the polarisome to track a moving pheromone input. Moreover, we find that only the stochastic model can simultaneously reproduce these characteristics of the wild-type phenotype and the multi-polarisome phenotype of a deletion mutant of the scaffolding protein Spa2. Significantly, our analysis also demonstrates that higher levels of stochastic noise results in increased robustness of polarization to parameter variation. Furthermore, our work suggests a novel role for a polarisome protein in the stabilization of actin cables. These findings elucidate the intricate role of spatial stochastic effects in cell polarity, giving support to a cellular model where noise and spatial heterogeneity combine to achieve robust biological function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.