ArticleInternational journal of medical sciences2013
Arrhythmogenesis toxicity of aconitine is related to intracellular ca(2+) signals.
Article in International journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- An Updated Meta-Analysis Based on the Preclinical Evidence of Mechanism of Aconitine-Induced Cardiotoxicity.Frontiers in pharmacology · 2022Pooled it
- Review
- Integrated toxicology ofFrontiers in pharmacology · 2025Review
- Mongolian medicine theory-based multidimensional evaluation of toxicity mitigation in Hezi-processed Caowu jointly mediated by powder dosage form and small dose.Frontiers in pharmacology · 2025Article
- A fatal intractable ventricular fibrillation triggered by improper use of Xiaozhong Jiuwei Powder: integrated LC-MS chemical profiling unveils the cardiotoxic culprits.Frontiers in medicine · 2025Article
- Review
- Case report: Accidental aconitine poisoning caused by the inappropriate use of a type of Chinese patent medicine.Frontiers in pharmacology · 2024Article
- Recurrent malignant ventricular arrhythmias and paresthesia-a mystery revealed as aconitine poisoning: a case report.Journal of medical case reports · 2023Article
- Mechanism of Danhong Injection in the Treatment of Arrhythmia Based on Network Pharmacology, Molecular Docking, andBioMed research international · 2022Article
- Processed lateral root ofFrontiers in pharmacology · 2022Review
- Synergistic and Attenuating Effect of Electroacupuncture on Aconitine in Improving Heart Failure and Its Calcium Regulation Mechanism.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Inhibition of the IActa pharmacologica Sinica · 2021Article
- Repeated Aconitine Treatment Induced the Remodeling of Mitochondrial FunctionFrontiers in pharmacology · 2021Article
- Aconitine Induces TRPV2-Mediated CaEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Risk Compounds, Preclinical Toxicity Evaluation, and Potential Mechanisms of Chinese Materia Medica-Induced Cardiotoxicity.Frontiers in pharmacology · 2021Review
- Wenxin Keli for the Treatment of Arrhythmia-Systems Pharmacology andFrontiers in pharmacology · 2021Article
- Potential Molecular Mechanisms and Drugs for Aconitine-Induced Cardiotoxicity in Zebrafish through RNA Sequencing and Bioinformatics Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Research progress of aconitine toxicity and forensic analysis of aconitine poisoning.Forensic sciences research · 2020Review
- Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms.Molecular medicine reports · 2018Article
- Aconitine-induced cardiac arrhythmia in human induced pluripotent stem cell-derived cardiomyocytes.Experimental and therapeutic medicine · 2018Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aconitine is a well-known arrhythmogenic toxin and induces triggered activities through cardiac voltage-gated Na(+) channels. However, the effects of aconitine on intracellular Ca(2+) signals were previously unknown. We investigated the effects of aconitine on intracellular Ca(2+) signals in rat ventricular myocytes and explored the possible mechanism of arrhythmogenic toxicity induced by aconitine. Ca(2+) signals were evaluated by measuring L-type Ca(2+) currents, caffeine-induced Ca(2+) release and the expression of NCX and SERCA2a. Action potential and triggered activities were recorded by whole-cell patch-clamp techniques. In rat ventricular myocytes, the action potential duration was significantly prolonged by 1 µM aconitine. At higher concentrations (5 µM and 10 µM), aconitine induced triggered activities and delayed after-depolarizations (6 of 8 cases), which were inhibited by verapamil. Aconitine (1 µM) significantly increased the ICa-L density from 12.77 ± 3.12 pA/pF to 18.98 ± 3.89 pA/pF (n=10, p<0.01). The activation curve was shifted towards more negative potential, while the inactivation curve was shifted towards more positive potential by 1 μM aconitine. The level of Ca(2+) release induced by 10 mM caffeine was markedly increased. Aconitine (1 µM) increased the expression of NCX, while SERCA2a expression was reduced. In conclusion, aconitine increased the cytosolic [Ca(2+)]i by accelerating ICa-L and changing the expression of NCX and SERCA2a. Then, the elevation of cytosolic [Ca(2+)]i induced triggered activities and delayed after-depolarizations. Arrhythmogenesis toxicity of aconitine is related to intracellular Ca(2+) signals.
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