ArticleJournal of immunology (Baltimore, Md. : 1950)2013
CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of multiple-dose ponesimod, a selective S1PDrug design, development and therapy · 2017Trial
- Transcriptomic rewiring of the JAK-STAT pathway in circulating CD4Frontiers in immunology · 2026Article
- Review
- Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target.Frontiers in immunology · 2021Review
- Evaluation of therapeutic targeting of CCR7 in acute graft-versus-host disease.Bone marrow transplantation · 2020Article
- Disease Stage-Specific Pathogenicity of CD138 (Syndecan 1)-Expressing T Cells in Systemic Lupus Erythematosus.Frontiers in immunology · 2020Article
- Dissemination of Chlamydia from the reproductive tract to the gastro-intestinal tract occurs in stages and relies on Chlamydia transport by host cells.PLoS pathogens · 2019Article
- Aquaporin 4 inhibition alters chemokine receptor expression and T cell trafficking.Scientific reports · 2019Article
- Lymph node γδ and αβ CD8Scientific reports · 2018Article
- Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis.Journal of virology · 2017Article
- A robust in vitro model for trans-lymphatic endothelial migration.Scientific reports · 2017Article
- Retention of Ag-specific memory CD4European journal of immunology · 2017Article
- The Lymphatic System: Integral Roles in Immunity.Annual review of immunology · 2017Review
- CC-chemokine receptor 7 (CCR7) deficiency alters adipose tissue leukocyte populations in mice.Physiological reports · 2016Article
- Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.Nature communications · 2016Article
- Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Molecular mechanisms of CD8(+) T cell trafficking and localization.Cellular and molecular life sciences : CMLS · 2015Review
- Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohn's-like murine ileitis.Journal of leukocyte biology · 2015Article
- Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory Responses to High Fat Diet-induced Obesity.The Journal of biological chemistry · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
CCR7⁻/⁻ mice exhibit profound anomalies in lymph node and spleen architecture, which complicates the study of CCR7-mediated T cell trafficking in vivo. To circumvent this problem, we established in vivo models in which wild-type and CCR7⁻/⁻ populations coexist within mice possessing normal lymphoid organs and must compete for developmental niches within the tissues of these mice. Under the conditions we have created in vivo, we find the entry of memory CD4 T cells into lymph nodes from the blood to be independent of CCR7. Thus, the central memory CD4 T cells that traffic though lymph nodes, which are often defined by their expression of CCR7, do not appear to gain any competitive homing advantage by expressing this receptor. Furthermore, in contrast to cutaneous dendritic cell populations, we found that CCR7 deficiency had no appreciable effect on the exit of CD4 T cells from inflamed skin. Finally, we found that wild-type and CCR7⁻/⁻ precursors were equally represented within the major thymic subpopulations, despite previous findings that CCR7 plays a role in seeding the thymus from bone marrow-derived T cell precursors.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.