ArticleGenetics2013
Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophila.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- An estimate of fitness reduction from mutation accumulation in a mammal allows assessment of the consequences of relaxed selection.PLoS biology · 2024Article
- Correlated responses to selection across diverse environments during experimental evolution ofEcology and evolution · 2024Article
- Review
- Experimental Evolution inMicroorganisms · 2022Review
- Temperature affects the repeatability of evolution in the microbial eukaryoteEcology and evolution · 2021Article
- Identification and Characterization of Base-Substitution Mutations in the Macronuclear Genome of the Ciliate Tetrahymena thermophila.Genome biology and evolution · 2021Article
- Phenotypic responses to temperature in the ciliateEcology and evolution · 2020Article
- Evolutionary origins and impacts of genome architecture in ciliates.Annals of the New York Academy of Sciences · 2019Review
- Limited Mutation-Rate Variation Within theG3 (Bethesda, Md.) · 2018Article
- Extremely Rare Polymorphisms in Saccharomyces cerevisiae Allow Inference of the Mutational Spectrum.PLoS genetics · 2017Article
- Low Base-Substitution Mutation Rate in the Germline Genome of the Ciliate Tetrahymena thermophil.Genome biology and evolution · 2016Article
- Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae.G3 (Bethesda, Md.) · 2016Article
- Hidden genetic variation in the germline genome of Tetrahymena thermophila.Journal of evolutionary biology · 2016Article
- Fitness is strongly influenced by rare mutations of large effect in a microbial mutation accumulation experiment.Genetics · 2014Article
- Mutational robustness of morphological traits in the ciliate Tetrahymena thermophila.The Journal of eukaryotic microbiologyArticle
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Authors and funding
4 authors.
Funding
Abstract
Knowledge of the rate and fitness effects of mutations is essential for understanding the process of evolution. Mutations are inherently difficult to study because they are rare and are frequently eliminated by natural selection. In the ciliate Tetrahymena thermophila, mutations can accumulate in the germline genome without being exposed to selection. We have conducted a mutation accumulation (MA) experiment in this species. Assuming that all mutations are deleterious and have the same effect, we estimate that the deleterious mutation rate per haploid germline genome per generation is U=0.0047 (95% credible interval: 0.0015, 0.0125), and that germline mutations decrease fitness by s=11% when expressed in a homozygous state (95% CI: 4.4%, 27%). We also estimate that deleterious mutations are partially recessive on average (h=0.26; 95% CI: -0.022, 0.62) and that the rate of lethal mutations is <10% of the deleterious mutation rate. Comparisons between the observed evolutionary responses in the germline and somatic genomes and the results from individual-based simulations of MA suggest that the two genomes have similar mutational parameters. These are the first estimates of the deleterious mutation rate and fitness effects from the eukaryotic supergroup Chromalveolata and are within the range of those of other eukaryotes.
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