Trial reportAmerican journal of physiology. Heart and circulatory physiology2013
Microvascular function in younger adults with obesity and metabolic syndrome: role of oxidative stress.
Trial report in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate.Physiological reports · 2019Trial
- Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance.Microcirculation (New York, N.Y. : 1994) · 2015Trial
- Cyclooxygenase-derived vasoconstriction restrains hypoxia-mediated cerebral vasodilation in young adults with metabolic syndrome.American journal of physiology. Heart and circulatory physiology · 2014Trial
- Age-Stratified Differences in Cardio-Reno-Metabolic Risk Profiles.Geriatrics (Basel, Switzerland) · 2026Article
- Evaluating the impact of type 2 diabetes mellitus on pulmonary vascular function and the development of pulmonary fibrosis.Frontiers in endocrinology · 2024Review
- International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin EPharmacological reviews · 2020Article
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Skeletal muscle performance in metabolic disease: Microvascular or mitochondrial limitation or both?Microcirculation (New York, N.Y. : 1994) · 2019Review
- Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes.Diabetology & metabolic syndrome · 2018Article
- Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.Journal of oncology · 2018Article
- Total Antioxidant Capacity from Dietary Supplement Decreases the Likelihood of Having Metabolic Syndrome in Korean Adults.Nutrients · 2017Article
- Microvascular Endothelial Dysfunction in Sedentary, Obese Humans Is Mediated by NADPH Oxidase: Influence of Exercise Training.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Peripheral Blood Flow Regulation in Human Obesity and Metabolic Syndrome.Exercise and sport sciences reviews · 2016Review
- Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men.Cardiovascular diabetology · 2016Article
- β-Adrenergic-mediated vasodilation in young men and women: cyclooxygenase restrains nitric oxide synthase.American journal of physiology. Heart and circulatory physiology · 2016Article
- Greater Beta-Adrenergic Receptor Mediated Vasodilation in Women Using Oral Contraceptives.Frontiers in physiology · 2016Article
- Exercise vasodilation is greater in women: contributions of nitric oxide synthase and cyclooxygenase.European journal of applied physiology · 2015Article
- Preserved Microvascular Endothelial Function in Young, Obese Adults with Functional Loss of Nitric Oxide Signaling.Frontiers in physiology · 2015Article
- Exercise-mediated vasodilation in human obesity and metabolic syndrome: effect of acute ascorbic acid infusion.American journal of physiology. Heart and circulatory physiology · 2014Article
- Di-peptidyl peptidase-4 inhibitor sitagliptin protects vascular function in metabolic syndrome: possible role of epigenetic regulation.Molecular biology reports · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Older adults with cardiovascular disease exhibit microvascular dysfunction and increased levels of reactive oxygen species (ROS). We hypothesized that microvascular impairments begin early in the disease process and can be improved by scavenging ROS. Forearm blood flow (Doppler ultrasound) was measured in 45 young (32 ± 2 yr old) adults (n = 15/group) classified as lean, obese, and metabolic syndrome (MetSyn). Vasodilation in response to endothelial (ACh) and vascular smooth muscle [nitroprusside (NTP) and epoprostenol (Epo)] agonists was tested before and after intra-arterial infusion of ascorbic acid to scavenge ROS. Vasodilation was assessed as a rise in relative vascular conductance (ml·min(-1)·dl(-1)·100 mmHg(-1)). ACh and NTP responses were preserved (P = 0.825 and P = 0.924, respectively), whereas Epo responses were lower in obese and MetSyn adults (P < 0.05) than in lean controls. Scavenging of ROS via infusion of ascorbic acid resulted in an increase in ACh-mediated (P < 0.001) and NTP-mediated (P < 0.001) relative vascular conductance across all groups, suggesting that oxidative stress influences vascular responsiveness in adults with and without overt cardiovascular disease risk. Ascorbic acid had no effect on Epo-mediated vasodilation (P = 0.267). These results suggest that obese and MetSyn adults exhibit preserved endothelium-dependent vasodilation with reduced dependence on prostacyclin and are consistent with an upregulation of compensatory vascular control mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.