ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Mechanistic insight into prolonged electromechanical delay in dyssynchronous heart failure: a computational study.
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Electromechanical wave imaging vs electrocardiographic imaging: a direct comparison of non-invasive ventricular activation mapping modalities.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Effect of exercise-induced muscle fatigue on reaction times under postural perturbation conditions in individuals with and without chronic low back pain.Frontiers in sports and active living · 2026Article
- Comparison of electrocardiogram parameters and echocardiographic response between distinct left bundle branch area pacing modes in heart failure patients.Frontiers in cardiovascular medicine · 2024Article
- Relationship between Fear-Avoidance Beliefs and Reaction Time Changes Prior to and following Exercise-Induced Muscle Fatigue in Chronic Low Back Pain.Pain research & management · 2024Article
- Simultaneous Widefield Voltage and Dye-Free Optical Mapping Quantifies Electromechanical Waves in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.ACS photonics · 2023Article
- Cardiac electro-mechanical activity in a deforming human cardiac tissue: modeling, existence-uniqueness, finite element computation and application to multiple ischemic disease.Journal of mathematical biology · 2022Article
- Sensitivity Analysis of Ion Channel Conductance on Myocardial Electromechanical Delay: Computational Study.Frontiers in physiology · 2021Article
- Comparison of Electromechanical Delay during Ventricular Tachycardia and Fibrillation under Different Conductivity Conditions Using Computational Modeling.Computational and mathematical methods in medicine · 2020Article
- 4D cardiac electromechanical activation imaging.Computers in biology and medicine · 2019Article
- The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study.Biomedical engineering online · 2018Article
- Computational analysis of the effect of mitral and aortic regurgitation on the function of ventricular assist devices using 3D cardiac electromechanical model.Medical & biological engineering & computing · 2018Article
- Influence of LVAD function on mechanical unloading and electromechanical delay: a simulation study.Medical & biological engineering & computing · 2018Article
- Computational Prediction of the Combined Effect of CRT and LVAD on Cardiac Electromechanical Delay in LBBB and RBBB.Computational and mathematical methods in medicine · 2018Article
- A two dimensional electromechanical model of a cardiomyocyte to assess intra-cellular regional mechanical heterogeneities.PloS one · 2017Article
- Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module.PLoS computational biology · 2015Article
- Computational analysis of the effect of valvular regurgitation on ventricular mechanics using a 3D electromechanics model.The journal of physiological sciences : JPS · 2015Article
- A New MRI-Based Model of Heart Function with Coupled Hemodynamics and Application to Normal and Diseased Canine Left Ventricles.Frontiers in bioengineering and biotechnology · 2015Article
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4 authors.
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Abstract
In addition to the left bundle branch block type of electrical activation, there are further remodeling aspects associated with dyssynchronous heart failure (HF) that affect the electromechanical behavior of the heart. Among the most important are altered ventricular structure (both geometry and fiber/sheet orientation), abnormal Ca(2+) handling, slowed conduction, and reduced wall stiffness. In dyssynchronous HF, the electromechanical delay (EMD), the time interval between local myocyte depolarization and myofiber shortening onset, is prolonged. However, the contributions of the four major HF remodeling aspects in extending EMD in the dyssynchronous failing heart remain unknown. The goal of this study was to determine the individual and combined contributions of HF-induced remodeling aspects to EMD prolongation. We used MRI-based models of dyssynchronous nonfailing and HF canine electromechanics and constructed additional models in which varying combinations of the four remodeling aspects were represented. A left bundle branch block electrical activation sequence was simulated in all models. The simulation results revealed that deranged Ca(2+) handling is the primary culprit in extending EMD in dyssynchronous HF, with the other aspects of remodeling contributing insignificantly. Mechanistically, we found that abnormal Ca(2+) handling in dyssynchronous HF slows myofiber shortening velocity at the early-activated septum and depresses both myofiber shortening and stretch rate at the late-activated lateral wall. These changes in myofiber dynamics delay the onset of myofiber shortening, thus giving rise to prolonged EMD in dyssynchronous HF.
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