ArticleJournal of community genetics2014
Patient compliance based on genetic medicine: a literature review.
Article in Journal of community genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06914726 (Randomized Trial to Improve Care of Patients With Hereditary Cancer Syndromes), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Trial to Improve Care of Patients With Hereditary Cancer Syndromes
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of communicating the genetic risk of cardiometabolic disorders on motivation and actual engagement in preventative lifestyle modification and clinical outcome: a systematic review and meta-analysis of randomised controlled trials.The British journal of nutrition · 2016Pooled it
- Trial
- Health actions after direct-to-consumer genetic testing for medically actionable conditions.Genetics in medicine open · 2026Article
- Patient Perspectives on Personalized Risk Communication Using Polygenic Risk Scores to Inform Colorectal Cancer Screening Decisions.AJPM focus · 2025Article
- Efficacy of polygenic risk scores and digital technologies for INNOvative personalized cardiovascular disease PREVention in high-risk adults: protocol of a randomized controlled trial.Frontiers in public health · 2024Article
- Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians' attitudes to sociocultural differences between patients across the globe.Translational psychiatry · 2022Review
- Systemic Barriers to Risk-Reducing Interventions for Hereditary Cancer Syndromes: Implications for Health Care Inequities.JCO precision oncology · 2021Review
- Risk management adherence following genetic testing for hereditary cancer syndromes: a Singaporean experience.Familial cancer · 2018Article
- "Where Does it Come from?" Experiences Among Survivors and Parents of Children with Retinoblastoma in Kenya.Journal of genetic counseling · 2018Article
- Knowledge, experiences and attitudes concerning genetics among retinoblastoma survivors and parents.European journal of human genetics : EJHG · 2018Article
- Communication of cancer-related genetic and genomic information: A landscape analysis of reviews.Translational behavioral medicine · 2018Review
- Improving Medication Adherence in Coronary Heart Disease.Current cardiology reports · 2017Review
- Retail genetics.Australian prescriber · 2017Article
- The Impact of Receiving Predictive Genetic Information about Lynch Syndrome on Individual Colonoscopy and Smoking Behaviors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
- Elucidating Genetic Counseling Outcomes from the Perspective of Genetic Counselors.Journal of genetic counseling · 2016Article
- Parents' Perspectives on Variants of Uncertain Significance from Chromosome Microarray Analysis.Journal of genetic counseling · 2016Article
- Assessing value of innovative molecular diagnostic tests in the concept of predictive, preventive, and personalized medicine.The EPMA journal · 2015Review
- The dawning age of genetic testing for sports injuries.Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2015Article
- Mechanisms and treatment of ischaemic stroke--insights from genetic associations.Nature reviews. Neurology · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For this literature review, medical literature data bases were searched for studies on patient compliance after genetic risk assessment. The review focused on conditions where secondary or tertiary preventive options exist, namely cancer syndromes (BRCA-related cancer, HNPCC/colon cancer), hemochromatosis, thrombophilia, smoking cessation, and obesity. As a counterpart, patient compliance was assessed regarding medication adherence and medical advice in some of the most epidemiologically important conditions (including high blood pressure, metabolic syndrome, and coronary heart disease) after receiving medical advice based on nongenetic risk information or a combination of genetic and nongenetic risk information. In the majority of studies based on genetic risk assessments, patients were confronted with predictive rather than diagnostic genetic profiles. Most of the studies started from a knowledge base around 10 years ago when DNA testing was at an early stage, limited in scope and specificity, and costly. The major result is that overall compliance of patients after receiving a high-risk estimate from genetic testing for a given condition is high. However, significant behavior change does not take place just because the analyte is "genetic." Many more factors play a role in the complex process of behavioral tuning. Without adequate counseling and guidance, patients may interpret risk estimates of predictive genetic testing with an increase in fear and anxiety.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.