ReviewNucleus (Austin, Tex.)
What we talk about when we talk about nuclear actin.
Review in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Myosin VI in the nucleolus of neurosecretory PC12 cells: its involvement in the maintenance of nucleolar structure and ribosome organization.Frontiers in physiology · 2024Article
- Genome organization: Tag it, move it, place it.Current opinion in cell biology · 2021Review
- Mechanism of Long-Range Chromosome Motion Triggered by Gene Activation.Developmental cell · 2020Article
- Indirect visualization of endogenous nuclear actin by correlative light and electron microscopy (CLEM) using an actin-directed chromobody.Histochemistry and cell biology · 2019Article
- Actin proteins assemble to protect the genome.Nature · 2018Article
- Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins.Nucleus (Austin, Tex.) · 2018Article
- A transient pool of nuclear F-actin at mitotic exit controls chromatin organization.Nature cell biology · 2017Article
- Laminin-111 and the Level of Nuclear Actin Regulate Epithelial Quiescence via Exportin-6.Cell reports · 2017Article
- Regulation of GVBD in mouse oocytes by miR-125a-3p and Fyn kinase through modulation of actin filaments.Scientific reports · 2017Article
- Plant actin depolymerizing factor: actin microfilament disassembly and more.Journal of plant research · 2017Review
- Actin, actin-binding proteins, and actin-related proteins in the nucleus.Histochemistry and cell biology · 2016Review
- Article
- Emerging roles of sumoylation in the regulation of actin, microtubules, intermediate filaments, and septins.Cytoskeleton (Hoboken, N.J.) · 2015Review
- Dyche Mullins: Finding filaments at the fringes.The Journal of cell biology · 2015Article
- Specification of Architecture and Function of Actin Structures by Actin Nucleation Factors.Annual review of biophysics · 2015Review
- Nuclear physics (of the cell, not the atom).Molecular biology of the cell · 2014Article
- Novel roles for actin in mitochondrial fission.Journal of cell science · 2014Article
- Article
- TORC2-a new player in genome stability.EMBO molecular medicine · 2014Article
- Formin' actin in the nucleus.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In the cytoplasm, actin filaments form crosslinked networks that enable eukaryotic cells to transport cargo, change shape, and move. Actin is also present in the nucleus but, in this compartment, its functions are more cryptic and controversial. If we distill the substantial literature on nuclear actin down to its essentials, we find four, recurring, and more-or-less independent, claims: (1) crosslinked networks of conventional actin filaments span the nucleus and help maintain its structure and organize its contents; (2) assembly or contraction of filaments regulates specific nuclear events; (3) actin monomers moonlight as subunits of chromatin remodeling complexes, independent of their ability to form filaments; and (4) modified actin monomers or oligomers, structurally distinct from canonical, cytoskeletal filaments, mediate nuclear events by unknown mechanisms. We discuss the evidence underlying these claims and as well as their strengths and weaknesses. Next, we describe our recent work, in which we built probes specific for nuclear actin and used them to describe the form and distribution of actin in somatic cell nuclei. Finally, we discuss how different forms of nuclear actin may play different roles in different cell types and physiological contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.