Evidence map›Paper›PMID 23933752›Full record

ArticleNature neuroscience2013

Intracortical multiplication of thalamocortical signals in mouse auditory cortex.

Ling-yun Li, Ya-tang Li, Mu Zhou, Huizhong W Tao, Li I Zhang

Abstract read
In one paragraph

Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The fluctuation-based regime of thalamocortical circuitry.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Distinct Inhibitory Neurons Differently Shape Neuronal Codes for Sound Intensity in the Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Synapse-type-specific competitive Hebbian learning forms functional recurrent networks.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Dissection of brain-wide resting-state and functional somatosensory circuits by fMRI with optogenetic silencing.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Ling-yun LiZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Ya-tang Li
Mu Zhou
Huizhong W Tao
Li I Zhang

Funding

Processing and transformation of visual signals in the superior colliculusR01EY019049 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TAO, HUIZHONG WHIT · 2008 to 2025
$9.2M
Thalamic Modulation of Auditory Cortical Processing via LPR01DC008983 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Li I Zhang · 2007 to 2026
$8.7M
NEI NIH HHS EY019049NEI NIH HHS R01 EY019049NIDCD NIH HHS DC008983NIDCD NIH HHS R01 DC008983
6 · The paper itself

Abstract

Cortical processing of sensory information begins with the transformation of thalamically relayed signals. We optogenetically silenced intracortical circuits to isolate thalamic inputs to layer 4 neurons and found that intracortical excitation linearly amplified thalamocortical responses underlying frequency and direction selectivity, with spectral range and tuning preserved, and prolonged the response duration. This signal pre-amplification and prolongation enhanced the salience of thalamocortically relayed information and ensured its robust, faithful and more persistent representation.

Indexed as

Acoustic StimulationAction PotentialsAfferent PathwaysAnimalsAuditory CortexChannelrhodopsinsDependovirusFemaleGreen Fluorescent ProteinsMiceOptogeneticsParvalbuminsPatch-Clamp TechniquesPhotic StimulationReaction TimeSensory Receptor CellsChannelrhodopsinsenhanced green fluorescent proteinGreen Fluorescent ProteinsParvalbumins

Identifiers

PMID23933752
PMCPMC3844430

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.