ArticleToxicology and applied pharmacology2013
Hemocompatibility and biocompatibility of antibacterial biomimetic hybrid films.
Article in Toxicology and applied pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- All-in-one: a CGRP-encapsulated Rh-GelMA supramolecular dual-network hydrogel orchestrating immune-vascular coupling for diabetic wound healing.Journal of nanobiotechnology · 2026Article
- Semi-IPN hydrogels of collagen and gum arabic with antibacterial capacity and controlled release of drugs for potential application in wound healing.Progress in biomaterials · 2023Article
- RETRACTED: A Polysaccharide Isolated from the HerbInternational journal of molecular sciences · 2022Article
- High-Carbohydrate Diet Alleviates the Oxidative Stress, Inflammation and Apoptosis ofAntioxidants (Basel, Switzerland) · 2021Article
- Microbicidal Dispersions and Coatings from Hybrid Nanoparticles of Poly (Methyl Methacrylate), Poly (Diallyl Dimethyl Ammonium) Chloride, Lipids, and Surfactants.International journal of molecular sciences · 2019Article
- Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview.RSC advances · 2019Review
- In Vitro models for thrombogenicity testing of blood-recirculating medical devices.Expert review of medical devices · 2019Review
- Effects of functionalized silver nanoparticles on aggregation of human blood platelets.International journal of nanomedicine · 2019Article
- Antimicrobial Coatings from Hybrid Nanoparticles of Biocompatible and Antimicrobial Polymers.International journal of molecular sciences · 2018Article
- Blood-Contacting Biomaterials:Frontiers in bioengineering and biotechnology · 2018Review
- Effect of Immobilized Antithrombin III on the Thromboresistance of Polycarbonate Urethane.Materials (Basel, Switzerland) · 2017Article
- Chemically grafted fibronectin for use in QCM-D cell studies.Biosensors & bioelectronics · 2014Article
- Designing nanogel carriers for antibacterial applications.Acta biomaterialia · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In previous work, we developed novel antibacterial hybrid coatings based on dextran containing dispersed Ag NPs (~5 nm, DEX-Ag) aimed to offer dual protection against two of the most common complications associated with implant surgery, infections and rejection of the implant. However, their blood-material interactions are unknown. In this study, we assess the hemocompatibility and biocompatibility of DEX-Ag using fresh blood and two cell lines of the immune system, monocytes (THP-1 cells) and macrophages (PMA-stimulated THP-1 cells). Glass, polyurethane (PU) and bare dextran (DEX) were used as reference surfaces. PU, DEX and DEX-Ag exhibited non-hemolytic properties. Relative to glass (100%), platelet attachment on PU, DEX and DEX-Ag was 15%, 10% and 34%, respectively. Further, we assessed cell morphology and viability, pro-inflammatory cytokines expression (TNF-α and IL-1β), pro-inflammatory eicosanoid expression (Prostaglandin E2, PGE2) and release of reactive oxygen species (ROS, superoxide and H2O2) following incubation of the cells with the surfaces. The morphology and cell viability of THP-1 cells were not affected by DEX-Ag whereas DEX-Ag minimized spreading of PMA-stimulated THP-1 cells and caused a reduction in cell viability (16% relative to other surfaces). Although DEX-Ag slightly enhanced release of ROS, the expression of pro-inflammatory cytokines remained minimal with similar levels of PGE2, as compared to the other surfaces studied. These results highlight low toxicity of DEX-Ag and hold promise for future applications in vivo.
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