ReviewNeuroscience2014
DNA methylation and childhood maltreatment: from animal models to human studies.
Review in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed.
- Early deprivation, atypical brain development, and internalizing symptoms in late childhood.Neuroscience · 2017Trial
- High-resolution metabolic profiling of the effects of early-life stress after peripheral nerve injury.The journal of pain · 2026Article
- Associations between life-course cognitive reserve and cognitive domains over 8 years in a large cohort of middle-aged and older adults: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association between negative life events through mental health and non-suicidal self-injury with young adults: evidence for sex moderate correlation.BMC psychiatry · 2024Article
- Early life stress modulates the genetic influence on brain structure and cognitive function in children.Heliyon · 2024Article
- Monoamine Oxidase: A Potential Link in Papez Circuit to Generalized Anxiety Disorders.CNS & neurological disorders drug targets · 2024Review
- Examining differences in brain metabolism associated with childhood maltreatment and suicidal attempt in euthymic patients with bipolar disorder: A PET and Machine Learning Study.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2023Article
- How can childhood maltreatment affect post-traumatic stress disorder in adult: Results from a composite null hypothesis perspective of mediation analysis.Frontiers in psychiatry · 2023Article
- Interplay Between Stress and Reproduction: Novel Epigenetic Markers in Response to Shearing Patterns in Australian Merino Sheep (Frontiers in veterinary science · 2022Article
- Potential epigenetic mechanisms in psychotherapy: a pilot study on DNA methylation and mentalization change in borderline personality disorder.Frontiers in human neuroscience · 2022Article
- Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Early life stress induces age-dependent epigenetic changes in p11 gene expression in male mice.Scientific reports · 2021Article
- Associations between childhood maltreatment and DNA methylation of the oxytocin receptor gene in immune cells of mother-newborn dyads.Translational psychiatry · 2021Article
- Harsh Parenting Predicts Novel HPA Receptor Gene Methylation and NR3C1 Methylation Predicts Cortisol Daily Slope in Middle Childhood.Cellular and molecular neurobiology · 2021Article
- Early Enriched Environment Prevents Epigenetic p11 Gene Changes Induced by Adulthood Stress in Mice.International journal of molecular sciences · 2021Article
- Epigenomic mediation after adverse childhood experiences: a systematic review and meta-analysis.Forensic sciences research · 2021Review
- Troubling Neurobiological Vulnerability: Psychiatric Risk and the Adverse Milieu in Environmental Epigenetics Research.Frontiers in sociology · 2021Article
- Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications.Nutrients · 2020Review
- Suicide: Genetics and Heritability.Current topics in behavioral neurosciences · 2020Article
- Epigenetics and Depression: An Update.Psychiatry investigation · 2019Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Childhood maltreatment (CM) has estimated prevalence among Western societies between 10% and 15%. As CM associates with increased risk of several psychiatric disorders, early age of illness onset, increased comorbidity and negative clinical outcome, it imposes a major public health, social and economic impact. Although the clinical consequences of CM are well characterized, a major challenge remains to understand how negative early-life events can affect brain function over extended periods of time. We review here both animal and human studies indicating that the epigenetic mechanism of DNA methylation is a crucial mediator of early-life experiences, thereby maintaining life-long neurobiological sequelae of CM, and strongly determining psychopathological risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.