ArticleDevelopmental biology2013
New regulatory circuit controlling spatial and temporal gene expression in the sea urchin embryo oral ectoderm GRN.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 49 citations in OpenAlex.
- Microbial communities experienced during early development shape the host immune system and epigenome.iScience · 2025Article
- An Integrated Canonical and Non-Canonical Wnt Signaling Network Controls Early Anterior-Posterior Axis Formation in Sea Urchin Embryos.Journal of developmental biology · 2025Review
- microRNA-124 directly suppresses Nodal and Notch to regulate mesodermal development.Developmental biology · 2023Article
- Article
- Developmental single-cell transcriptomics in the Lytechinus variegatus sea urchin embryo.Development (Cambridge, England) · 2021Article
- Developmental gene regulatory network connections predicted by machine learning from gene expression data alone.PloS one · 2021Article
- Genetic basis for divergence in developmental gene expression in two closely related sea urchins.Nature ecology & evolution · 2020Article
- BMP controls dorsoventral and neural patterning in indirect-developing hemichordates providing insight into a possible origin of chordates.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Divergence of ectodermal and mesodermal gene regulatory network linkages in early development of sea urchins.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Developmental gene regulatory networks in sea urchins and what we can learn from them.F1000Research · 2016Review
- Genome-wide assessment of differential effector gene use in embryogenesis.Development (Cambridge, England) · 2015Article
- Comparative Study of Regulatory Circuits in Two Sea Urchin Species Reveals Tight Control of Timing and High Conservation of Expression Dynamics.PLoS genetics · 2015Article
- Geometric control of ciliated band regulatory states in the sea urchin embryo.Development (Cambridge, England) · 2015Article
- Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo.PloS one · 2015Article
- Early asymmetric cues triggering the dorsal/ventral gene regulatory network of the sea urchin embryo.eLife · 2014Article
- Specific functions of the Wnt signaling system in gene regulatory networks throughout the early sea urchin embryo.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Symmetry breakage in the vertebrate embryo: when does it happen and how does it work?Developmental biology · 2014Review
- General approach for in vivo recovery of cell type-specific effector gene sets.Genome research · 2014Article
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3 authors at 1 institution in 1 country.
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Abstract
The sea urchin oral ectoderm gene regulatory network (GRN) model has increased in complexity as additional genes are added to it, revealing its multiple spatial regulatory state domains. The formation of the oral ectoderm begins with an oral-aboral redox gradient, which is interpreted by the cis-regulatory system of the nodal gene to cause its expression on the oral side of the embryo. Nodal signaling drives cohorts of regulatory genes within the oral ectoderm and its derived subdomains. Activation of these genes occurs sequentially, spanning the entire blastula stage. During this process the stomodeal subdomain emerges inside of the oral ectoderm, and bilateral subdomains defining the lateral portions of the future ciliary band emerge adjacent to the central oral ectoderm. Here we examine two regulatory genes encoding repressors, sip1 and ets4, which selectively prevent transcription of oral ectoderm genes until their expression is cleared from the oral ectoderm as an indirect consequence of Nodal signaling. We show that the timing of transcriptional de-repression of sip1 and ets4 targets which occurs upon their clearance explains the dynamics of oral ectoderm gene expression. In addition two other repressors, the direct Nodal target not, and the feed forward Nodal target goosecoid, repress expression of regulatory genes in the central animal oral ectoderm thereby confining their expression to the lateral domains of the animal ectoderm. These results have permitted construction of an enhanced animal ectoderm GRN model highlighting the repressive interactions providing precise temporal and spatial control of regulatory gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.