ArticleCurrent biology : CB2013
Dauer-specific dendrite arborization in C. elegans is regulated by KPC-1/Furin.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it.
- FMRFamide-like peptides expand the behavioral repertoire of a densely connected nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2017Pooled it
- Mating strategies in Caenorhabditis elegans populations are determined by male developmental history.G3 (Bethesda, Md.) · 2026Article
- NDR kinase SAX-1 controls dendrite branch-specific elimination during neuronal remodeling in C. elegans.The EMBO journal · 2026Article
- Nictation behavior in nematodes.BMC biology · 2025Review
- Insulin and epidermal signals independently shape sexually dimorphic neurite branching in C. elegans.EMBO reports · 2025Article
- Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution.Science (New York, N.Y.) · 2025Article
- The PVD neuron has male-specific structure and mating function inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner at C. elegans excitatory synapses.PLoS biology · 2025Article
- The many roads toJournal of biosciences · 2025Review
- ZA-II-05, a novel NMDA-receptor antagonist reverses vanadium-induced neurotoxicity in Caenorhabditis elegans (C. elegans).BMC neuroscience · 2024Article
- Neurogenesis in Caenorhabditis elegans.Genetics · 2024Review
- The kpc-1 3'UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship.PLoS genetics · 2024Article
- Glial expression of a steroidogenic enzyme underlies natural variation in hitchhiking behavior.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Dendrite morphogenesis in Caenorhabditis elegans.Genetics · 2024Review
- Comparative connectomics of dauer reveals developmental plasticity.Nature communications · 2024Article
- Transcriptional and spatiotemporal regulation of the dauer program.Transcription · 2023Review
- Semantic Representation of Neural Circuit Knowledge inbioRxiv : the preprint server for biology · 2023Article
- Convertase-dependent regulation of membrane-tethered and secreted ligands tunes dendrite adhesion.Development (Cambridge, England) · 2023Article
- The proprotein convertase BLI-4 promotes collagen secretion prior to assembly of the Caenorhabditis elegans cuticle.PLoS genetics · 2023Article
- Ribo-On and Ribo-Off tools using a self-cleaving ribozyme allow manipulation of endogenous gene expression in C. elegans.Communications biology · 2023Article
5 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
backgroundDendrites often display remarkably complex and diverse morphologies that are influenced by developmental and environmental cues. Neuroplasticity in response to adverse environmental conditions entails both hypertrophy and resorption of dendrites. How dendrites rapidly alter morphology in response to unfavorable environmental conditions is unclear. The nematode Caenorhabditis elegans enters into a stress-resistant dauer larval stage in response to an adverse environment.
resultsHere we show that the IL2 bipolar sensory neurons undergo dendrite arborization and axon remodeling during dauer development. When dauer larvae are returned to favorable environmental conditions, animals resume reproductive development and IL2 dendritic branches retract, leaving behind remnant branches in postdauer L4 and adult animals. The C. elegans furin homolog KPC-1 is required for dauer IL2 dendritic arborization and dauer-specific nictation behavior. KPC-1 is also necessary for dendritic arborization of PVD and FLP sensory neurons. In mammals, furin is essential, ubiquitously expressed, and associated with numerous pathologies, including neurodegenerative diseases. While broadly expressed in C. elegans neurons and epithelia, KPC-1 acts cell autonomously in IL2 neurons to regulate dauer-specific dendritic arborization and nictation.
conclusionsNeuroplasticity of the C. elegans IL2 sensory neurons provides a paradigm to study stress-induced and reversible dendritic branching, and the role of environmental and developmental cues in this process. The newly discovered role of KPC-1 in dendrite morphogenesis provides insight into the function of proprotein convertases in nervous system development.
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