Evidence map›Paper›PMID 23932234›Full record

ReviewBlood cells, molecules & diseases2013

Erythroid development in the mammalian embryo.

Margaret H Baron, Andrei Vacaru, Johnathan Nieves

Abstract readReview
In one paragraph

Review in Blood cells, molecules & diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Frontiers in immunology · 2025
    Review
  3. Article
  4. Immunoregulation role of the erythroid cells.Frontiers in immunology · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Long noncoding RNABlood science (Baltimore, Md.) · 2019
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. RNA-seq reveals conservation of function among the yolk sacs of human, mouse, and chicken.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Margaret H BaronDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: margaret.baron@mssm.edu.
Andrei Vacaru
Johnathan Nieves

Funding

Induction and Specification of Hematopoietic MesodermR01HL062248 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BARON, MARGARET H · 2000 to 2016
$5.5M
INDUCTION OF YOLK SAC HEMATOPOIETIC MESODERM BY BMP-4R01DK052191 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BARON, MARGARET H · 1997 to 2011
$4.2M
Methods for Modulating Hemato-Vascular DevelopmentR01EB002209 · NIBIB · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BARON, MARGARET H. · 2003 to 2007
$1.7M
NHLBI NIH HHS R01 HL062248NHLBI NIH HHS R01 HL62248NIBIB NIH HHS EB02209NIBIB NIH HHS R01 EB002209NIDDK NIH HHS DK52191NIDDK NIH HHS R01 DK052191
6 · The paper itself

Abstract

Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells have evolved highly specialized functions in oxygen transport, defense against oxidation, and vascular remodeling. Here we review key features of the ontogeny of red blood cell development in mammals, highlight similarities and differences revealed by genetic and gene expression profiling studies, and discuss methods for identifying erythroid cells at different stages of development and differentiation.

Indexed as

AnimalsCell DifferentiationCell LineageEmbryo, MammalianErythroid CellsErythropoiesisGene Expression Regulation, DevelopmentalHumansLiverTranscription, GeneticYolk SacAGMaorta–gonad–mesonephrosBFU-Ebipotential megakaryocyte/erythroid progenitorburst-forming unit erythroidCFU-Ecolony-forming cells erythroiddefinitive, enucleated erythrocytesE#embryonic day post-fertilizationembryonic stemEMPEryDEryPErythroid differentiationerythroid–myeloid progenitorerythroid–tropomodulinESESREE-Tmodextensively self-renewing erythroidFetal liverGFPgreen fluorescent proteinhigh proliferating progenitors-colony forming cellHPP-CFCMammalian embryoMEPPrimitive erythropoiesisprimitive (nucleated) erythrocytesTransgenic miceYolk sac

Identifiers

PMID23932234
PMCPMC3812334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.