SynthesisDiabetes research and clinical practice2013
Impact of low-density lipoprotein cholesterol on cardiovascular outcomes in people with type 2 diabetes: a meta-analysis of prospective cohort studies.
Synthesis in Diabetes research and clinical practice, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Guideline
- Impact of different dietary approaches on blood lipid control in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis.European journal of epidemiology · 2019Pooled it
- Baseline diabetes as a way to predict CV outcomes in a lipid-modifying trial: a meta-analysis of 330,376 patients from 47 landmark studies.Cardiovascular diabetology · 2015Pooled it
- Dapagliflozin does not impair LDL catabolism and induces a shift towards a closer to normal VLDLDiabetologia · 2026Trial
- Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trial.Cardiovascular diabetology · 2019Trial
- Understanding the Relationship Between Weight Discrimination and Cardiometabolic Risk Factors in Diabetes: Findings from the English Longitudinal Study of Ageing (ELSA).International journal of behavioral medicine · 2026Article
- High-density lipoprotein cholesterol and kidney disease progression in patients with type 2 diabetes mellitus: the Fukushima Cohort Study.BMJ open diabetes research & care · 2025Observational
- Phenotyping lipid profiles in type 2 diabetes: Risk association and outcomes from the Cardiovascular Health Study.American journal of preventive cardiology · 2024Article
- Trends in obesity prevalence and cardiometabolic risk factor control in US adults with diabetes, 1999-2020.Obesity (Silver Spring, Md.) · 2023Article
- Longitudinal Adherence to Diabetes Quality Indicators and Cardiac Disease: A Nationwide Population-Based Historical Cohort Study of Patients With Pharmacologically Treated Diabetes.Journal of the American Heart Association · 2022Article
- Identifying Patient Profiles for Developing Tailored Diabetes Self-Management Interventions: A Latent Class Cluster Analysis.Risk management and healthcare policy · 2022Article
- Association between lipoprotein cholesterol and future cardiovascular disease and mortality in older adults: a Korean nationwide longitudinal study.Lipids in health and disease · 2021Article
- Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes.PloS one · 2021Article
- Japanese Clinical Practice Guideline for Diabetes 2019.Diabetology international · 2020Review
- Japanese Clinical Practice Guideline for Diabetes 2019.Journal of diabetes investigation · 2020Article
- Diabetes classification model based on boosting algorithms.BMC bioinformatics · 2018Article
- Japanese Clinical Practice Guideline for Diabetes 2016.Journal of diabetes investigation · 2018Article
- Japanese Clinical Practice Guideline for Diabetes 2016.Diabetology international · 2018Review
- Mean platelet volume changes before and after glycated hemoglobin (HbAArchives of medical science : AMS · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
aimsTo estimate the prospective association of low-density lipoprotein (LDL) cholesterol on cardiovascular disease (CVD) risk among people with type 2 diabetes.
methodsWe used extensive literature searching strategies to locate prospective cohort studies that reported LDL cholesterol levels as a risk factor for cardiovascular events. We conducted meta-analytic procedures for two outcomes: incident CVD and CVD mortality.
resultsA total of 16 studies were included in this analysis with a mean follow-up range of 4.8-11 years. The pooled relative risk associated with a 1mmol/L increase in LDL cholesterol in people with type 2 diabetes was 1.30 (95% confidence interval [CI], 1.19-1.43) for incident CVD, and 1.50 (95% CI, 1.25-1.80) for CVD mortality, respectively. Subgroup analyses showed that for incident CVD, the pooled relative risk was 1.28 (95% CI, 1.17-1.41) for 7 studies adjusted for blood pressure and/or glucose concentration (or insulin concentration, glycated hemoglobin) and 1.40 (95% CI, 1.05-1.86) for 3 studies that did not adjust for these variables.
conclusionsOur study demonstrates that LDL cholesterol was associated with an increased risk for cardiovascular outcomes in people with type 2 diabetes, independent of other conventional risk factor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.