ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2014
Treatment of metabolic acidosis in patients with CKD.
Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Rethinking Potassium Management in Chronic Kidney Disease-A Modern Approach.Journal of clinical medicine · 2025Review
- Safety and efficacy of sodium bicarbonate for treating metabolic acidosis in chronic kidney disease: A systematic review and meta-analysis.World journal of nephrology · 2025Article
- Neurocirculatory regulation and adaptations to exercise in chronic kidney disease.American journal of physiology. Heart and circulatory physiology · 2023Review
- Serum bicarbonate levels and gait abnormalities in older adults: a cross-sectional study.Scientific reports · 2022Article
- Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseases.American journal of physiology. Lung cellular and molecular physiology · 2022Review
- Complications of metabolic acidosis and alkalinizing therapy in chronic kidney disease patients: a clinician-directed organ-specific primer.International urology and nephrology · 2020Review
- Veverimer for treatment of chronic metabolic acidosis in patients with chronic kidney disease.Annals of translational medicine · 2020Article
- Advances in management of chronic metabolic acidosis in chronic kidney disease.Current opinion in nephrology and hypertension · 2019Review
- Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis.CEN case reports · 2018Article
- Oral alkali therapy and the management of metabolic acidosis of chronic kidney disease: A narrative literature review.World journal of nephrology · 2018Review
- Relationship of acid-base status with arterial stiffness in community-living elders: the Health ABC Study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- The impact of high serum bicarbonate levels on mortality in hemodialysis patients.The Korean journal of internal medicine · 2017Observational
- Effect of oral sodium bicarbonate on fibroblast growth factor-23 in patients with chronic kidney disease: a pilot study.BMC nephrology · 2016Article
- NH4Cl Treatment Prevents Tissue Calcification in Klotho Deficiency.Journal of the American Society of Nephrology : JASN · 2015Article
- Effect of dietary protein restriction on renal ammonia metabolism.American journal of physiology. Renal physiology · 2015Article
- High (≥6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy.International journal of nephrology · 2015Article
- Acid-base balance and physical function.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- Persistent Metabolic Acidosis on Regular Hemodialysis or Peritoneal Dialysis.Indian journal of nephrologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Metabolic acidosis is a common complication of chronic kidney disease and is believed to contribute to a number of sequelae, including bone disease, altered protein metabolism, skeletal muscle wasting, and progressive glomerular filtration rate loss. Small trials in animal models and humans suggest a role for alkali therapy to lessen these complications. Recent studies support this notion, although more definitive evidence is needed on the long-term benefits of alkali therapy and the optimal serum bicarbonate level. The role of dietary modification also should be given greater consideration. In addition, potential adverse effects of alkali treatment must be taken into consideration, including sodium retention and the theoretical concern of promoting vascular calcification. This teaching case summarizes the rationale for and benefits and complications of base therapy in patients with chronic kidney disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.