ArticleNeuron2013
Spatial segregation of adaptation and predictive sensitization in retinal ganglion cells.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Article
- Filter, Detector, Predictor: The expanding repertoire of retinal computation in vertebrates.Vision research · 2026Review
- Sensory adaptation supports flexible evidence accumulation during perceptual decision making.bioRxiv : the preprint server for biology · 2026Article
- Surround motion modulates the encoding properties of primate retinal ganglion cells.Cell reports · 2026Article
- Integration of Visual Motion Signals in Reduced Visual Conditions.Investigative ophthalmology & visual science · 2025Article
- Neural networks with optimized single-neuron adaptation uncover biologically plausible regularization.PLoS computational biology · 2024Article
- Article
- Temporal pattern recognition in retinal ganglion cells is mediated by dynamical inhibitory synapses.Nature communications · 2024Article
- GABA receptors mediate adaptation and sensitization processes in mouse retinal ganglion cells.Cognitive neurodynamics · 2024Article
- Calibrating Vision: Concepts and Questions.Vision research · 2022Review
- Remembering the Past to See the Future.Annual review of vision science · 2021Article
- Efficient and adaptive sensory codes.Nature neuroscience · 2021Article
- How inhibitory neurons increase information transmission under threshold modulation.Cell reports · 2021Article
- On the potential role of lateral connectivity in retinal anticipation.Journal of mathematical neuroscience · 2021Article
- Adjudicating Between Local and Global Architectures of Predictive Processing in the Subcortical Auditory Pathway.Frontiers in neural circuits · 2021Review
- Functional-pathway-dominant contrast adaptation and sensitization in mouse retinal ganglion cells.Cognitive neurodynamics · 2020Article
- Computational challenges and opportunities for a bi-directional artificial retina.Journal of neural engineering · 2020Article
- Article
- High Contrast Allows the Retina to Compute More Than Just Contrast.Frontiers in cellular neuroscience · 2020Article
- Neural sensitization improves encoding fidelity in the primate retina.Nature communications · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Sensory systems change their sensitivity based on recent stimuli to adjust their response range to the range of inputs and to predict future sensory input. Here, we report the presence of retinal ganglion cells that have antagonistic plasticity, showing central adaptation and peripheral sensitization. Ganglion cell responses were captured by a spatiotemporal model with independently adapting excitatory and inhibitory subunits, and sensitization requires GABAergic inhibition. Using a simple theory of signal detection, we show that the sensitizing surround conforms to an optimal inference model that continually updates the prior signal probability. This indicates that small receptive field regions have dual functionality--to adapt to the local range of signals but sensitize based upon the probability of the presence of that signal. Within this framework, we show that sensitization predicts the location of a nearby object, revealing prediction as a functional role for adapting inhibition in the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.