ArticleBiophysical journal2013
Cellular pressure and volume regulation and implications for cell mechanics.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 218 citations in OpenAlex.
- Real-Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hydrostatic pressure shapes and canalizes semicircular canal morphology to ensure vestibular function.bioRxiv : the preprint server for biology · 2026Article
- Electrodiffusion active pump model with asymmetric immersed chemical potentials.bioRxiv : the preprint server for biology · 2026Article
- Article
- Stress-dependent growth in breast cancer arises from a mechano-osmotic coupling and cell-sizing checkpoint.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Pore size dynamics control complex volume swelling in pyroptosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Single-cell chiral symmetry breaking under confinement.bioRxiv : the preprint server for biology · 2026Article
- Influence of Magneto-Mechanical Stress on Cellular Membranes, Ion Channel Activity, and Gene Expression Dynamics.Results and problems in cell differentiation · 2026Review
- The RNA-binding protein RNP1A is essential and interacts with contractility kit proteins to facilitate cell mechanics.Journal of cell science · 2026Article
- Mass Transfer in Cryopreservation at Multiple Scales: Cells, Tissues, and Organs.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Cell volume regulates terminal differentiation of cultured human epidermal keratinocytes.Journal of cell science · 2025Article
- Mechanical memory of excitable cells induced by mechanosensitive channel inactivation.Biophysical journal · 2025Article
- CaBMC biology · 2025Article
- Separation of ionic timescales explains dynamics of cellular volume regulation.Biophysical journal · 2025Article
- Article
- Fluid and solute transport by cells and a model of systemic circulation.PLoS computational biology · 2025Article
- The role of RAP2 in regulation of cell volume on bone marrow mesenchymal stem cell fate determination.Journal of molecular histology · 2025Article
- Unifying fragmented perspectives with additive deep learning for high-dimensional models from partial faceted datasets.npj biological physics and mechanics · 2025Article
- Incorporating the thermodynamic effects of temperature and pressure on modeling neuronal gating kinetics.PloS one · 2025Article
- Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation.Cell reports · 2024Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In eukaryotic cells, small changes in cell volume can serve as important signals for cell proliferation, death, and migration. Volume and shape regulation also directly impacts the mechanics of cells and tissues. Here, we develop a mathematical model of cellular volume and pressure regulation, incorporating essential elements such as water permeation, mechanosensitive channels, active ion pumps, and active stresses in the cortex. The model can fully explain recent experimental data, and it predicts cellular volume and pressure for several models of cell cortical mechanics. Moreover, we show that when cells are subjected to an externally applied load, such as in an atomic force microscopy indentation experiment, active regulation of volume and pressure leads to a complex cellular response. Instead of the passive mechanics of the cortex, the observed cell stiffness depends on several factors working together. This provides a mathematical explanation of rate-dependent response of cells under force.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.