ArticleTissue engineering. Part A2014
Building an anisotropic meniscus with zonal variations.
Article in Tissue engineering. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Precision repair of zone-specific meniscal injuries using a tunable extracellular matrix-based hydrogel system.Bioactive materials · 2025Article
- Suspension bath bioprinting and maturation of anisotropic meniscal constructs.Biofabrication · 2023Article
- Meniscus heterogeneity and 3D-printed strategies for engineering anisotropic meniscus.International journal of bioprinting · 2023Article
- Advances in Regenerative Sports Medicine Research.Frontiers in bioengineering and biotechnology · 2022Review
- Collagen: quantification, biomechanics, and role of minor subtypes in cartilage.Nature reviews. Materials · 2020Article
- Engineering self-assembled neomenisci through combination of matrix augmentation and directional remodeling.Acta biomaterialia · 2020Article
- Functional MRI Mapping of Human Meniscus Functionality and its Relation to Degeneration.Scientific reports · 2020Observational
- Surgical and tissue engineering strategies for articular cartilage and meniscus repair.Nature reviews. Rheumatology · 2019Review
- Considerations for translation of tissue engineered fibrocartilage from bench to bedside.Journal of biomechanical engineering · 2018Article
- Current Concepts in Meniscus Tissue Engineering and Repair.Advanced healthcare materials · 2018Review
- Cell-Free Strategies for Repair and Regeneration of Meniscus Injuries through the Recruitment of Endogenous Stem/Progenitor Cells.Stem cells international · 2018Review
- Tendon and ligament as novel cell sources for engineering the knee meniscus.Osteoarthritis and cartilage · 2016Article
- Mechanical Stimulation Increases Knee Meniscus Gene RNA-level Expression in Adipose-derived Stromal Cells.Plastic and reconstructive surgery. Global open · 2016Article
- Platelet-Rich Plasma Increases the Levels of Catabolic Molecules and Cellular Dedifferentiation in the Meniscus of a Rabbit Model.International journal of molecular sciences · 2016Article
- Cell-Based Strategies for Meniscus Tissue Engineering.Stem cells international · 2016Review
- Harnessing biomechanics to develop cartilage regeneration strategies.Journal of biomechanical engineering · 2015Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Toward addressing the difficult problems of knee meniscus regeneration, a self-assembling process has been used to re-create the native morphology and matrix properties. A significant problem in such attempts is the recapitulation of the distinct zones of the meniscus, the inner, more cartilaginous and the outer, more fibrocartilaginous zones. In this study, an anisotropic and zonally variant meniscus was produced by self-assembly of the inner meniscus (100% chondrocytes) followed by cell seeding the outer meniscus (coculture of chondrocytes and meniscus cells). After 4 weeks in culture, the engineered, inner meniscus exhibited a 42% increase in both instantaneous and relaxation moduli and a 62% increase in GAG/DW, as compared to the outer meniscus. In contrast, the circumferential tensile modulus and collagen/DW of the outer zone was 101% and 129% higher, respectively, than the values measured for the inner zone. Furthermore, there was no difference in the radial tensile modulus between the control and zonal engineered menisci, suggesting that the inner and outer zones of the engineered zonal menisci successfully integrated. These data demonstrate that not only can biomechanical and biochemical properties be engineered to differ by the zone, but they can also recapitulate the anisotropic behavior of the knee meniscus.
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Registered trials
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